Publications by authors named "Mc Stephen Padilla"
Article Synopsis
- Colorectal cancer (CRC) is a major global health issue, necessitating effective surveillance through colonoscopy to identify patients at high or low risk of advanced colorectal neoplasia (ACN).
- This study critically reviewed nine risk models that predict the occurrence of metachronous ACN, finding mixed results in validation and limitations in methodology across the studies examined.
- While some models showed potential for clinical use, there is a need for better validation and comparisons of these models in diverse populations to enhance CRC surveillance practices.
Post-traumatic stress disorder (PTSD) is a debilitating mental health condition for which current treatments have long-term efficacy in 50% of patients. There is a clear need for better understanding of the mechanisms underlying PTSD and the development of new treatment approaches. Analog trauma procedures in animals, such as the stress-enhanced fear learning (SEFL) procedure, can be used to produce behavioral and neurobiological changes that have validity in modeling PTSD.
View Article and Find Full Text PDFTrazodone and patient outcomes in dementia-Limitations of naturalistic cohort data.
Int J Geriatr Psychiatry
August 2022
Article Synopsis
- The unfolded protein response is a key pathway in neurodegeneration, and trazodone, an antidepressant, may have therapeutic potential in this area.
- A study of dementia patients in Cambridgeshire showed that trazodone is rarely prescribed and often at ineffective doses.
- Patients who were prescribed trazodone showed more neuropsychiatric symptoms and were further along in their disease, indicating that more controlled studies are needed before dismissing trazodone's potential benefits.