Publications by authors named "Mbaga D"
Background: Methicillin-resistant (MRSA) is a significant cause of morbidity and mortality among neonates admitted to neonatal intensive care units (NICUs). The MRSA colonization of neonates, attributed to various sources, including mothers, healthcare workers, and environmental surfaces, can lead to severe infection, prolonged hospital stays, and even death, imposing substantial economic burdens. Given the pressing need to mitigate MRSA spread in these vulnerable environments, further examination of the subject is warranted.
View Article and Find Full Text PDFDialysis is a replacement therapy for patients with End-Stage Renal Disease (ESRD). Patients on dialysis are at high risk of acquiring hepatitis C virus (HCV), which has become a leading cause of morbidity and mortality in this population. There is a wide range of prevalence of HCV in dialysis populations around the world.
View Article and Find Full Text PDFInfluenza, a highly contagious acute respiratory disease, remains a major global health concern. This study aimed to comprehensively assess the prevalence of influenza virus in different aquatic environments. Using 43 articles from four databases, we thoroughly examined water matrices from wastewater treatment plants (WTPs) and other human environments, as well as poultry habitats and areas frequented by migratory wild birds.
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- HIV is a significant public health issue in Africa, particularly affecting pregnant women, which impacts both maternal and child health.
- The study reviewed 248 articles to determine the overall HIV seroprevalence among pregnant women in Africa, finding a rate of 9.3%, with notable regional differences.
- The highest seroprevalence was in Southern Africa (29.4%), while Northern Africa had the lowest (0.7%), indicating considerable variation in HIV rates across the continent.
Background: The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has increased and poses a significant threat to human and animal health in Cameroon and the world at large. MRSA strains have infiltrated various settings, including hospitals, communities, and livestock, contributing to increased morbidity, treatment costs, and mortality. This evidence synthesis aims to understand MRSA prevalence, resistance patterns, and genetic characterization in Cameroon.
View Article and Find Full Text PDFAstroviruses (AstVs) are a major cause of gastroenteritis, especially in children. They can be transmitted through various pathways, including environmental contamination via water matrices. This study aimed to investigate the prevalence of AstV in different types of water, such as untreated and treated wastewater, surface water (e.
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- Rotavirus infections are a leading cause of diarrhea-related deaths in children under 5 globally, with various transmission routes that are not fully understood.
- A study analyzed data from multiple sources and found that 29.8% of patients with gastroenteritis had rotavirus, indicating a high prevalence, especially among young children.
- The findings highlight the significant health burden of rotavirus in Africa and call for a One Health approach, integrating human, animal, and environmental health strategies to combat the virus.
Exploring adenovirus in water environments: a systematic review and meta-analysis.
Int J Environ Health Res
June 2024
Adenoviruses (AdVs) have a significant impact in both medical and environmental contexts. The objective of this study was to investigate the prevalence of AdV in different water types, such as untreated and treated wastewater, surface water, groundwater, drinking water, and other water matrices. A total of 239 articles were included in this meta-analysis.
View Article and Find Full Text PDFRift Valley fever (RVF) is a severe zoonotic mosquito-borne disease that represents an important threat to human and animal health, with major public health and socioeconomic impacts. This disease is endemic throughout many African countries and the Arabian Peninsula. This systematic review with meta-analysis was conducted to determine the RVF prevalence in humans, mosquitoes and other animal species in Africa.
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- The study aimed to estimate the prevalence of metabolic syndrome (MS) in African populations, noting its global health impact and prior lack of specific prevalence data for Africa.
- It conducted a systematic review of 297 studies across 29 African countries, analyzing the prevalence rates using various diagnostic methods, which revealed a pooled prevalence of 32.4% for MS overall in Africa.
- The results indicated higher prevalence in adults (33.1%) than children (13.3%), with MS being more common in females (36.9%) versus males (26.7%), and particularly prevalent among patients with Type 2 diabetes (66.9%).
Occurrence of Hepatitis A Virus in Water Matrices: A Systematic Review and Meta-Analysis.
Int J Environ Res Public Health
January 2023
Hepatitis A is a common form of viral hepatitis. It is usually transmitted through the ingestion of contaminated food and water. This systematic review was carried out to summarise the overall prevalence of Hepatitis A virus (HAV) in different water matrices: untreated and treated wastewater, surface water, groundwater, drinking water, and others (e.
View Article and Find Full Text PDFSeroprevalence of hepatitis C virus antigen in patients with chronic liver disease and hepatocellular carcinoma at 12 week of treatment: a cross-sectional study.
Pan Afr Med J
January 2023
Introduction: epidemiological data suggests that more than 50% of hepatitis C virus (HCV) patients fail treatment. The objective of the study was to highlight the seroprevalence of hepatitis C virus antigen (HCV Ag) at the 12 week of treatment.
Methods: during a cross-sectional study, participants with chronic liver disease and hepatocellular carcinoma (HCC) were recruited between December 2020 and March 2022 at the Yaoundé General Hospital (HGY) and the University Teaching Hospital of Yaounde (UTHY).
Article Synopsis
- Occult hepatitis B (OBI) and C (OCI) infections are serious health issues in Africa, leading to liver complications like cirrhosis and cancer, and pose risks for transmission.
- A systematic review and meta-analysis examined OBI and OCI prevalence across Africa, utilizing data from multiple published studies.
- The findings indicated that OBI has a prevalence of about 14.8%, while OCI is around 10.7%, with higher rates observed in specific patient populations such as those with liver disorders and malignancies.
Background: The association between hospitalization for human respiratory syncytial virus (HRSV) bronchiolitis in early childhood and subsequent asthma is well established. The long-term prognosis for non-bronchiolitis lower respiratory tract infections (LRTI) caused by viruses different from HRSV and rhinovirus, on the other hand, has received less interest.
Aim: To investigate the relationship between infant LRTI and later asthma and examine the influence of confounding factors.
Hepatitis E Virus in Water Environments: A Systematic Review and Meta-analysis.
Food Environ Virol
September 2022
Hepatitis E virus (HEV) is responsible for acute hepatitis in humans, through foodborne, zoonotic, and waterborne transmission routes. This study aimed to assess the prevalence of HEV in water matrices. Six categories were defined: untreated and treated wastewater, surface water (river, lake, and seawater), drinking water, groundwater, and other water environments (irrigation water, grey water, reservoir water, flood water, and effluent of pig slaughterhouse).
View Article and Find Full Text PDFThis study aimed to assess the global prevalence of occult hepatitis B in blood donors. We searched PubMed, Web of Science, Global Index Medicus, and Excerpta Medica Database. Study selection and data extraction were performed by at least two independent investigators.
View Article and Find Full Text PDFSeroprevalence of Epstein-Barr virus, hepatitis B virus, hepatitis C virus, and human immunodeficiency virus among patients with non-Hodgkin's lymphoma at the Yaounde General Hospital, Cameroon.
Pan Afr Med J
August 2022
The non-Hodgkin's lymphomas (NHLs) are a diverse group of malignancies that originate in lymphoid cells, heterogeneous in clinical behavior, morphology, cellular origin, etiology, and pathogenesis. A viral infectious etiology had been associated with them. This study aimed to investigate the seroprevalence of Epstein-Barr virus (EBV), Hepatitis B virus (HBV), Hepatitis C virus (HCV) and Human Immunodeficiency Virus (HIV) among patients with NHL at the Yaoundé General Hospital (YGH).
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- Yellow fever (YF) has seen a resurgence over the past two decades, leading to outbreaks in endemic areas and new regions, which poses significant public health challenges.
- This systematic review analyzed data on the case fatality rate (31.1% in humans) and the prevalence of the yellow fever virus (YFV) in humans (9.4%), mosquitoes, and non-human primates in sub-Saharan Africa, based on 55 studies.
- The findings emphasize the ongoing virus transmission and highlight the urgent need for strategies like the WHO's Eliminate Yellow Fever Epidemics initiative to prevent future outbreaks in the region.
Background: Occult hepatitis C infection (OCI) is characterized by the presence of hepatitis C virus (HCV) RNA in the liver, peripheral blood mononuclear cells (PBMC) and/or ultracentrifuged serum in the absence of detectable HCV-RNA in serum. OCI has been described in several categories of populations including hemodialysis patients, patients with a sustained virological response, immunocompromised individuals, patients with abnormal hepatic function, and apparently healthy subjects.
Aim: To highlight the global prevalence of OCI.
Article Synopsis
- In Africa, HIV coinfection with hepatitis B (HBV) and hepatitis C (HCV) is a significant public health issue, yet data on its epidemiology and case fatality rates are limited.
- A systematic review of 4388 articles identified 314 studies, revealing a 4.4% case fatality rate for HBV among people living with HIV (PLHIV) and various prevalence rates for HBV (10.5%), HCV (5.4%), and their coinfection (0.7%).
- The findings highlight the need for targeted public health efforts to address the complex interplay of these infections in Africa, given the observed variability and challenges in data reporting.
A substantial amount of epidemiological data has been reported on Enterovirus D68 (EV-D68) infections after the 2014 outbreak. Our goal was to map the case fatality rate (CFR) and prevalence of current and past EV-D68 infections. We conducted a systematic review (PROSPERO, CRD42021229255) with published articles on EV-68 infections in PubMed, Embase, Web of Science and Global Index Medicus up to January 2021.
View Article and Find Full Text PDFIntroduction: Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and D (VHD) viruses were etiological agents of HCC in Africa.
Methods: Relevant articles were searched in PubMed, Web of Science, African Index Medicus, and African Journal Online databases, as well as manual searches in relevant reviews and included articles.
Article Synopsis
- The systematic review aimed to assess the relationship between diabetes mellitus (DM) and the risk of developing tuberculosis (TB), addressing confounders like age, gender, and lifestyle factors that previous studies may have overlooked.
- A total of 12,796 articles were screened, leading to the inclusion of 47 observational studies with over half a million DM or TB cases, and results indicated a significant association with an odds ratio of 2.3, meaning diabetics were more than twice as likely to develop TB compared to non-diabetics.
- The study confirmed that the increased TB risk persisted across various study types (cohort, case-control, cross-sectional) and was influenced by geographic differences, though the statistical significance remained consistent
The outbreak of coronavirus infectious disease-2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world. Several studies have shown that detecting SARS-CoV-2 in untreated wastewater can be a useful tool to identify new outbreaks, establish outbreak trends, and assess the prevalence of infections. On 06 May 2021, over a year into the pandemic, we conducted a scoping review aiming to summarize research data on SARS-CoV-2 in sewage.
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- Hepatitis B virus (HBV) is a major global health issue, impacting around 2 billion people and causing about 1 million deaths annually, with healthcare workers (HCWs) at high risk due to potential exposure to infected blood.
- This study aims to assess the global prevalence of HBV serological markers among HCWs by analyzing relevant research published between 1970 and 2019, including a total of 227 studies from 71 countries.
- The meta-analysis revealed a pooled prevalence of current HBV infection (2.3%), with very low rates for HBeAg (0.2%) among the HCW population, highlighting the importance of monitoring and improving HBV control strategies in healthcare settings.