Flipped classroom model versus conventional teaching method: effects on nursing students' self-directed learning readiness in a research methodology course.

Introduction: the effectiveness of the flipped classroom model (FCM) method for building self-directed learning readiness (SDLR) in a research methodology course has not yet been scientifically researched. This study aims to assess the effect of FCM on SDLR among Nigerian nursing students enrolled in a research methodology course.

Methods: sixty-four 400-level nursing students from two government-owned universities in Southeast Nigeria were recruited for this quasi-experimental study.

COVID-19 information seeking pattern and perceived benefits in Nigeria: a cross-sectional survey.

Introduction: access to COVID-19 related information is fundamental to making accurate decisions and performing evidence-based actions aimed to control its spread and improve health. This study assessed pattern and perceived benefits of COVID-19 related information in Nigeria.

Methods: a descriptive cross-sectional survey was carried out among adult Nigerian residents aged 18-years and above in the geopolitical zones using multistage sampling strategy.

Perceived accessibility, and adequacy of COVID-19 related information in Nigeria.

Information on COVID-19 has evolved and blended with fake news, which the public, unfortunately, has to make an individual decision on how to use. As a result, access to authentic and adequate health information on COVID-19 is crucial for curbing the ongoing pandemic. The study was aimed at identifying sources of information on COVID-19 commonly used by adult Nigerian residents; determine the adequacy of information received; determine the accessibility of information on COVID-19 among Nigerians, and explore the relationship between location and access to information.

Brain activities of streptozotocin-induced diabetic Wistar rats treated with gliclazide: Behavioural, biochemical and histomorphology studies.

Gliclazide (GLD), a sulphonylurea is efficacious in the treatment of diabetes type-2. However, there is limited information on its activity in the brain, especially in diabetics. This research investigated the brain activities of GLD following streptozotocin-induced diabetes in Wistar rats.

Self-reported compliance with routine prenatal medications by pregnant women in a tertiary hospital in Enugu State, Nigeria.

Introduction: Compliance to routine antenatal medications increases a woman's chances of achieving a normal pregnancy and having a healthy baby. However, non-compliance is a commonly encountered problem in developing countries including Nigeria. This study investigated compliance to routine antenatal medications as reported by pregnant women receiving antenatal care in a tertiary hospital in Enugu State, Nigeria.

Metabolic characterisation of THP-1 macrophage polarisation using LC-MS-based metabolite profiling.

Introduction: Macrophages constitute a heterogeneous population of functionally distinct cells involved in several physiological and pathological processes. They display remarkable plasticity by changing their phenotype and function in response to environmental cues representing a spectrum of different functional phenotypes. The so-called M1 and M2 macrophages are often considered as representative of pro- and anti-inflammatory ends of such spectrum.

Prevalence of mental illness among adolescents (15-18 years) treated at Federal Neurospsychiatric Hospital, Enugu Nigeria, from 2004 to 2013.

Purpose: The aim of this study was to investigate the prevalence of mental illness among adolescents treated at Federal Neurospsychiatric Hospital, Enugu Nigeria.

Methods: A retrospective descriptive design was used to assess 1255 adolescents within the age of 15-18 years diagnosed with mental illness from 2004 to 2013. A proforma designed by the researchers was used to document information on prevalence, type, and relationship with age and gender.

Adult male involvement in maternity care in Enugu State, Nigeria: A cross-sectional study.

Introduction: Men are the key decision makers in the family and play a crucial role in the reproductive health of partners, in Nigeria. This study assessed adult male involvement in maternity care in Enugu south local government area, Enugu State, Nigeria.

Methods: This community-based study was conducted using a cross-sectional survey design.

The awareness, perceptions and experiences of primary open angle glaucoma patients in Lagos Nigeria.

The awareness, perceptions and experiences of Nigerian Primary Open Angle Glaucoma (POAG) patients were assessed using a hospital based cross-sectional study design. One hundred and twenty POAG patients attending a glaucoma clinic in Lagos Nigeria were recruited consecutively. They underwent face-to-face interviews with trained interviewers using a semi-structured questionnaire and an interview guide consisting of open-ended questions.

Pattern of conjunctival masses seen at Guinness Eye Centre Luth Idi-Araba.

Background: Conjunctival masses are growth on the surface of the outer eye; which may represent benign or malignant transformations.

Objective: To determine the pattern of presentation of conjunctival masses at the Guinness Eye Centre (GEC), Lagos University Teaching Hospital (LUTH) Idi-Araba over a 13 year period (Jan 1995-Dec 2007).

Method: A retrospective review of the clinical notes of all patients that presented to GEC with conjunctival masses during the study period was carried out.

A comparison of the NEIVFQ25 and GQL-15 questionnaires in Nigerian glaucoma patients.

Aim: To compare two vision-specific quality of life (QOL) instruments - the disease-specific 15-item Glaucoma Quality of Life questionnaire (GQL-15) and the nonglaucoma-specific 25-item National Eye Institute Visual Function Questionnaire (NEIVFQ25).

Methods: The QOL of 132 glaucoma patients being managed in Lagos University Teaching Hospital and an equal number of controls matched for age and sex was assessed using two vision-specific instruments: GQL-15 and the NEIVFQ25. The categorization of the severity of glaucoma into mild, moderate, and severe disease was determined using the degree of visual field loss.

Aetiology of vitreous haemorrhage in Guinness Eye Centre, Lagos University Teaching Hospital over a two year period (June 2007-May 2009).

Background: The Vitreous Humour is the transparent biological gel which fills the posterior 5/6th of the eyeball. Extravasations of blood into this delicate tissue may cause visual loss.

Objective: The study was to determine the causes and pattern of vitreous haemorrhage in Guinness eye centre, Lagos University Teaching Hospital.

Quality of life of primary open angle glaucoma patients in lagos, Nigeria: clinical and sociodemographic correlates.

Purpose: To evaluate the quality of life (QOL) of primary open angle glaucoma (POAG) patients attending a tertiary eye institution in Lagos, Nigeria and identify clinical and sociodemographic factors affecting it.

Methods: A hospital-based cross-sectional analytical study design was used to compare 132 patients with varying degrees of severity of glaucoma (cases) with age-matched and sex-matched controls with essentially normal eyes and no family history of glaucoma.

Results: POAG patients had reduced QOL as defined by the 2 instruments used: the National Eye Institute Visual Function Questionnaire25 (NEIVFQ25) and the 15-item Glaucoma Quality of life Questionnaire (GQL-15).

Ouabain-induced changes in aqueous humour outflow facility and trabecular meshwork cytoskeleton.

Background: Inhibition of the Na,K-ATPase by ouabain results in decreased intraocular pressure (IOP), by mechanisms that are not completely understood. Cellular mechanisms that regulate aqueous humour outflow through the trabecular meshwork (TM) include changes in the TM cytoskeleton. Because inhibition of the Na,K-ATPase by ouabain alters the cell's cytoskeleton, the role of the ouabain in regulating aqueous humour outflow and TM cytoskeleton was investigated.

NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel.

Nitric oxide (NO) donors decrease intraocular pressure (IOP) by increasing aqueous outflow facility in the trabecular meshwork (TM) and/or Schlemm's canal. However, the cellular mechanisms are unknown. Cellular mechanisms known to regulate outflow facility include changes in cell volume and cellular contractility.