Publications by authors named "Mba-Tihssommah Mosore"
In the last 2 decades, there has been an increase in the geographic range and frequency of vector-borne diseases. Management of mosquito populations has become challenging due to increasing rates of resistance to existing insecticidal products and formulations. Several alternative tools have emerged to suppress or replace mosquito populations.
View Article and Find Full Text PDFTicks are important disease vectors affecting animal health and causing substantial economic loss, especially in the tropics and subtropics. To examine the tick burden of cattle and associated risk factors for tick infestation, ticks were collected from 388 cattle within five regions in Ghana. Most of the cattle were males (50.
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- The study highlights the risk of infection from tick-borne diseases, particularly for people in Ghana, including military personnel and livestock, which serve as hosts for pathogens.
- Researchers identified and analyzed a total of 1,493 adult ticks from three genera and discovered a significant presence (56.9%) of Rickettsia species using molecular techniques.
- The first molecular detection of Rickettsia aeschlimannii and Rickettsia africae in these ticks was reported, indicating a pressing need for control measures to mitigate human infections in Ghana and further research into their clinical impact.
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- The study investigated gopher tortoise burrows as potential overwintering sites for mosquitoes and identified four species, with Culex erraticus being the most prevalent during winter.
- The presence of mosquito species in these burrows could maintain virus activity, as some host animals like tortoises are capable of carrying viruses like West Nile and Eastern equine encephalitis.
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- Dengue fever is becoming a significant global health issue, with sporadic cases reported in Cameroon over the past few decades, prompting a study on the genetic profile of DENV-1 strains from this region.
- Researchers conducted genomic analyses using phylogenetic methods to trace the outbreak's origin, revealing the Cameroonian strains are closely related to a 2012 strain from Gabon and estimate their most recent common ancestor dates back to around 2008.
- Comparing the new strains to existing vaccines showed notable amino acid differences, indicating potential challenges for immunotherapy and vaccine effectiveness, necessitating continued monitoring and further research into therapeutic options for DENV in Africa.
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- Leishmaniasis, caused by parasites spread by infected female sand flies, occurs in the Volta Region of Ghana, prompting a study in the Tsatee community to identify sand fly species and detect parasite DNA.
- Researchers collected 4,580 sand flies over five months using traps, with 99.91% identified as a specific species, and found a low infection rate of the parasite DNA in both individual and pooled sand flies.
- The study highlights the importance of ongoing surveillance and research on blood meal preferences and vector competence to better understand and control the transmission of leishmaniasis in the area.
Genetic and phylogenetic analysis was performed on 2 isolates of Leishmania using DNA sequence data from the RNA polymerase II large subunit gene and the ribosomal protein L23a intergenic sequence. This showed the isolates to represent 2 new species within the subgenus Leishmania (Mundinia). The addition of Leishmania (Mundinia) chancei and Leishmania (Mundinia) procaviensis creates a total of 6 named species to date within this recently described subgenus of parasitic protozoa, containing both human pathogens and nonpathogens.
View Article and Find Full Text PDFLeishmaniasis is a parasitic disease that mostly affects populations in tropical and subtropical countries. In Ghana, cutaneous leishmaniasis (CL) is the most common form of the disease affecting communities of the Volta Region. Conventional parasitological method (microscopy) is the commonly used test for CL diagnosis in many endemic countries, but has low sensitivity in chronic cases.
View Article and Find Full Text PDFBackground: Chikungunya virus (CHIKV) is a re-emerging arbovirus associated with sporadic outbreaks in Cameroon since 2006. Viral whole genomes were generated to analyze the origins of evolutionary lineages, the potential of emergence/re-emergence, and to infer transmission dynamics of recent Cameroon CHIKV outbreak strains.
Methods: Samples collected between 2016 and 2019 during CHIKV outbreaks in Cameroon were screened for CHIKV using reverse transcription PCR (RT-PCR), followed by whole genome sequencing of positive samples.
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- * A cross-sectional study tested over 3,000 individuals in three communities, showing an overall Leishmania exposure prevalence of 41.8%, with variations among communities (39.4%, 55.1%, and 34.2%).
- * The findings indicate that being male, living in Keri, and being in specific age groups (5-65 years) are associated with higher exposure odds, highlighting the need for targeted efforts to reduce
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- Cutaneous leishmaniasis (CL) is a prevalent parasitic infection in Ghana, particularly noted in the Volta region where Leishmania parasites have been found in individuals with skin ulcers.
- A study conducted in three communities of the Oti Region revealed a 31.9% prevalence of CL among participants with skin ulcers, with significant variation in prevalence across the communities (23.2% to 36.8%).
- The findings indicate an active transmission cycle of the Leishmania infection, highlighting the need for further research to explore other causes of skin ulcers in the area.
Background: Cutaneous leishmaniasis causes physical disfigurement and impairment on affected individuals, however, little attention has been paid to it eradication. The situation of this neglected disease is complicated with the expansion of the non-human pathogenic complex causing infection in humans. We have previously shown that the extract from has leishmanicidal activity against promastigote stages of the complex isolate from Ghana and .
View Article and Find Full Text PDFLeishmaniasis is an infectious disease transmitted by the sand fly. It is caused by over 20 different species of Leishmania and has affected over 14 million people worldwide. One of the main forms of control of leishmaniasis is chemotherapy, but this is limited by the high cost and/or toxicity of available drugs.
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- - An active case detection method using PCR was implemented in the Ho District, Ghana, to identify people with active cutaneous leishmaniasis.
- - Three distinct isolates were cultured, and DNA analysis revealed they were Leishmania parasites that were similar to each other but different from other known species.
- - Phylogenetic analysis indicated these parasites belong to a new group within the Leishmania enriettii complex, which may represent a potential new subgenus of human pathogenic Leishmania.