Publications by authors named "Mazurier E"

Background: Traditional approaches to management of neonates prenatally exposed to opioids are based on the use of pharmacotherapy (PT), adjusted to evolution of infant symptoms. Newer approaches focused on non-pharmacological care (NPC) are emerging, but there is little evidence on the active policies to implement to ensure their widespread practice. The primary objective of the study was to assess whether the implementation of a developmental care program in our neonatal medicine department had an impact on the management of these infants during hospitalization, notably exposure to NPC.

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Based on their clinical practice and an extensive review of the literature, the authors propose a framework of procedures to be followed to provide services to all women of childbearing age who use psychoactive substances (alcohol, cannabis, cocaine, amphetamines, and opioids), especially during pregnancy or during the postpartum and breastfeeding periods, in view of their individual situations and environmental contexts.

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Background: Long-chain polyunsaturated fatty acids (LC-PUFAs) are important for newborn neurosensory development. Supplementation of breastfeeding mothers' diets with omega-3 PUFAs, such as alpha-linolenic acid (ALA), may increase their concentration in human milk. Research aim: This study aimed to assess human milk composition after 15-day supplementation regimens containing either omega-3 PUFAs or olive oil, which does not provide ALA.

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Background: Studies on infant outcomes of opiate-dependent pregnant women find a high rate of premature mother-child separation and to a lesser extent developmental delay. The specific role of in utero heroin exposure in the determination of the developmental outcome seems to be less important than the home environment.

Objective: Describe the health and development of 5-year-old children whose drug-addict mothers allowed an early multidisciplinary intervention (medical and psychological) in the maternity hospital and neonatology.

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Background: Since the early 90s a striking rise in deformational plagiocephaly (DP) has been reported, and a causal link between the "back to sleep" position recommended to reduce the risk of sudden infant death syndrome. Recent data suggested that supine position is a risk factor only when combined with other environmental factors

Objective: To evaluate the impact of early intervention in the newborn environment on the prevalence of DP at 4 months of life.

Methods: A multicentric, prospective, controlled study in healthy term neonates.

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Article Synopsis
  • The study aimed to assess if early postpartum discharge (ED) from the hospital affects breastfeeding practices compared to conventional discharge (CD) in mothers.
  • Conducted with 135 breastfeeding mothers, the results showed similar rates of exclusive breastfeeding between ED (77.8%) and CD (71.1%) groups, with no significant differences in satisfaction or reasons for switching feeding methods.
  • The research concluded that early discharge, when managed by professionals, does not negatively impact breastfeeding rates, suggesting formal support programs could further encourage breastfeeding continuity.
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In a family of Spanish origin, five individuals presented a heterozygous alpha(0)-thalassemia (alpha-thal)-like phenotype. All had a -alpha(3.7) deletion with the recombinant alpha gene carrying the Hb Suan-Dok [alpha109(G16)LeuArg] mutation, proposed to be thalassemic.

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Aim: To compare the duration of treatment for neonatal abstinence syndrome (NAS) using chlorpromazine versus morphine hydrochloride.

Methods: We compared two case series of term infants with NAS treated with either morphine hydrochloride (MH) or chlorpromazine (CP). Seventeen infants were treated with MH from 1998 to 1999, and 20 infants were managed with CP from 2000 to 2001.

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Thirty-six unrelated cases with erythrocytosis of unknown origin were investigated. Exons 5-8 of the erythropoietin receptor gene (EPOR), the von Hippel-Lindau gene, and the prolyl hydroxylase domain protein 2 gene (PHD2) were screened by direct DNA sequencing. The Janus kinase 2 mutation, JAK2 (Val617Phe), was screened by allele specific PCR.

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Unlabelled: In France the organization of the care in perinatality is governed by the decrees of October 1998 and was specified by the "plan périnatalité" 2005-2007. This organization allowed an operation in network, declined in a variable way according to areas. In this context, the group of the paediatricians in Languedoc-Roussillon took concrete action of harmonization of the reference frames of care of paediatrics in maternity.

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Purpose: Drug abuse during pregnancy is an important public health problem. Montpellier University Hospital established a center for addiction and pregnancy in 1997 to provide multidisciplinary prenatal care aimed at reducing maternal and fetal risks during pregnancy and afterwards. This study assesses the trends in drug-taking behavior and pregnancy outcome among women receiving this prenatal care.

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Aim: To assess the intelligence quotient (IQ) and academic achievement in early adulthood of a cohort of extremely-low-birthweight (ELBW 1000 g) subjects.

Methods: All 82 ELBW survivors consecutively born in or referred to a single tertiary center in 1976-1981 were traced at a mean age of 18 y. Three disabled children had died.

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Article Synopsis
  • A case was reported of a child with renal issues due to severe low amniotic fluid (anhydramnios) linked to maternal use of the medication valsartan during the first 28 weeks of pregnancy.
  • The mother, who had hypertension, was taking valsartan alongside other medications; after stopping valsartan, the child's renal condition improved, leading to only mild chronic renal insufficiency by age 2.5 years.
  • Research suggests that exposure to angiotensin II receptor antagonists like valsartan in pregnancy can cause serious fetal complications, and these medications should generally be avoided to prevent potential harm to the fetus.
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