Investigations into the use of machine learning to predict drug dosage form design to obtain desired release profiles for 3D printed oral medicines.

Three-dimensional (3D) printing, digitalization, and artificial intelligence (AI) are gaining increasing interest in modern medicine. All three aspects are combined in personalized medicine where 3D-printed dosage forms are advantageous because of their variable geometry design. The geometry design can be used to determine the surface area to volume (SA/V) ratio, which affects drug release from the dosage forms.

Behavioral activation system moderates self-referent processing following recovery from depression.

Background: Previous research has implicated the behavioral activation system (BAS) in depression. The relationship of BAS functioning to aspects of cognitive vulnerability to depression, however, is not known. Method The present study investigated associations among level of BAS functioning and the encoding and recall of positive and negative self-referent information in currently non-depressed participants with a history of recurrent major depression (recovered; RMD) and in never-depressed control participants (CTL).

[Content of metals in vegetables from various regions of poland in the years 1986-1988. II. Content of zinc and copper].

The content of zinc and copper was determined in various sorts of vegetables grown in hothouses or on soil. This content was determined also in the soil where these vegetables were grown. The samples of these vegetables were taken directly from the producers in 18 provinces of Poland from the areas not contaminated by industrial plants and traffic.

[Content of metals in vegetables from various regions of Poland in the years 1986-1988. I. Content of lead, cadmium and mercury].

The content of lead, cadmium and mercury was determined in various sorts of Polish vegetables grown on soil or in hothouses in the years 1986-1988 using for the determination of Pb and Cd the extraction flame ASA method after dry mineralization at about 400 degrees C and for Hg the flameless ASA method after wet mineralization. In 1988 soil investigations were conducted parallelly in the areas where these vegetables had been grown. Vegetable samples were taken directly from the producers in 18 provinces, from areas not contaminated with these metals by industrial plants and traffic.

[Examination of plastic food-packaging materials].

The aim of the work was evaluation of the hygienic quality of plastic packaging material and its elements intended for direct contact with food products. The study carried out in the years 1986-1989 comprised 3066 samples taken from 20 provinces. A considerable number of the studied materials had no attest of the State Institute of Hygiene (19.

Stability of intravenous famotidine stored in polyvinyl chloride syringes.

The stability of intravenous famotidine in dextrose 5% injection (D5W), NaCl 0.9% injection (NS), and sterile water for injection stored in polyvinyl chloride (PVC) syringes at 4 degrees C for 14 days was studied. The concentration of famotidine samples was determined at time 0, 7 days, and 14 days by reverse-phase high-performance liquid chromatography.

Extraction of diethylhexylphthalate from total nutrient solution-containing polyvinyl chloride bags.

Total nutrient solution (TNS) is a new method for delivering total parenteral nutrition (TPN) by admixing dextrose, amino acids, and lipids in a single container. Recommendations are to use nonpolyvinyl chloride (PVC) containers for admixture of these solutions. PVC is a hard, brittle, and inflexible substance, and plasticizers, predominantly diethylhexylphthalate (DEHP), are added to impart flexibility.