Inhibitory killer cell immunoglobulin-like receptor KIR3DL1 in combination with HLA-B Bw4iso protect against ankylosing spondylitis.

Background: The HLA class I molecules serve as ligands for both T cell receptors and killer cell immunoglobulin-like receptors (KIRs).

Objective: We investigated the HLA-C and HLA-Bw4 alleles as well as KIRs expression on CD56 positive lymphocytes to evaluate whether these genes and molecules could influence Ankylosing Spondylitis (AS) susceptibility, alone or in combination.

Methods: We typed 40 AS patients and 40 normal controls for HLA-C asn⁸⁰ (group 1) and HLA-C lys⁸⁰ (group 2), HLA-B Bw4(thero), HLA-B Bw4(iso) and HLA-A Bw4 alleles by PCR-SSP method.

Phenotypic study of natural killer cell subsets in ankylosing spondylitis patients.

It has been demonstrated that natural killer (NK) cells play a role in regulation of autoimmunity. They play a protective role in several rodent disease models. In this study we aimed to compare the immunophenotypic features of NK cells in Ankylosing Spondylitis (AS) with normal subjects with regard to CD56 and CD16 molecules.

CpG Immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrations.

Background: Mucosal-based immunotherapy has been already used as an alternative form of allergen delivery. In asthma, the poor success rate of immune modulation could be a consequence of inadequate immune modulation in the airways. Previously, we have found that subcutaneous (S.

The prevalence of oral aphthosis in a normal population in Iran: a WHO-ILAR COPCORD study.

This study was conducted to determine the prevalence of oral aphthosis in a normal population in Iran, using the data of the WHO-ILAR COPCORD study in Iran. We conducted this study in Tehran, the capital of Iran which was selected as the COPCORD study field. In 22 districts of Tehran, 50 clusters were randomly selected.