leaves: phytochemical profile and -inhibitory activity on inflammatory mediators implicated in periodontal disease.

Context: Virtually all parts of L. (Salvadoraceae) are used in traditional medicine. The twigs and leaves are used for oral health, but leaves are far less investigated.

Clinical, phenotypic, and genotypic characteristics of ESBL-producing bloodstream infections from Qatar.

Background: Resistant infections are a major global public health challenge particularly for multidrug-resistant (MDR) isolates manifesting as bloodstream infections (BSIs).

Objectives: To evaluate clinical, phenotypic, and genotypic characteristics of extended-spectrum beta-lactamase (ESBL) producing BSIs from Qatar.

Methods: Phenotypic ESBL from adult patients presenting with positive BSIs were collected between January 2019 to May 2020.

Outcome of Respiratory Viral Infections in Hematopoietic Stem Cell Transplant Recipients.

Background: Respiratory viral infections (RVIs) commonly cause morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients. This study aimed at the prevalence of RVIs in adult HSCT recipients and their outcomes.

Methods: A retrospective observational cohort study was conducted on all adult patients who underwent HSCT in the period between January 2016 and December 2020.

Prevalence and genetic characterization of clinically relevant extended-spectrum β-lactamase-producing in the Gulf Cooperation Council countries.

Introduction: Among Gram-negative bacteria (GNB), (), such as () and (), are the most clinically relevant pathogens in healthcare settings. Infections secondary to these pathogens are widely common but multidrug resistance (MDR) in has become a significant challenge with increased morbidity, mortality, and cost of management. The escalating global prevalence of MDR in has led to limited treatment options, raising an urgent need for novel antimicrobial therapy(s) and detailed studies exploring underlying resistance mechanisms.

Early-onset burdensome multimorbidity: an exploratory analysis of sentinel conditions, condition accrual sequence and duration of three long-term conditions using the 1970 British Cohort Study.

Objectives: The prevalence of multiple long-term condition (LTC) multimorbidity is increasing with younger onset among socioeconomically deprived populations. Research on life course trajectories towards multimorbidity is limited and early-onset multimorbidity poorly characterised. Understanding sentinel conditions (the first LTC occurring in the life course), the sequence of LTC accrual and the permanency of the reporting of LTCs may help identify time points for prevention efforts.

Evaluation of Activity of Ceftazidime/Avibactam and Ceftolozane/Tazobactam against ESBL-producing Enterobacterales Isolated from Intensive Care Units from Qatar.

Objectives: Extended-spectrum -lactamases (ESBLs) mechanism of resistance in Enterobacterales leads to poor clinical outcomes. Ceftazidime/avibactam and ceftolozane/tazobactam are two broad-spectrum antimicrobial combinations that are effective against multidrug-resistant organisms with regional variations. This study aims to evaluate the antimicrobial susceptibility test (AST) for both combinations against ESBL-producing Enterobacterales isolated from intensive care units (ICUs) in tertiary hospitals from November 2012 to October 2013 in Qatar.

COVID-19 Oximetry @home: evaluation of patient outcomes.

Background: COVID-19 has placed unprecedented demands on hospitals. A clinical service, COVID-19 Oximetry @home (CO@h) was launched in November 2020 to support remote monitoring of COVID-19 patients in the community. Remote monitoring through CO@h aims to identify early patient deterioration and provide timely escalation for cases of silent hypoxia, while reducing the burden on secondary care.

Factors that influence adult neurogenesis as potential therapy.

Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain. The potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative disorders.

Calcium oxalate formation in Lemna minor: physiological and ultrastructural aspects of high capacity calcium sequestration.

•  The function of calcium oxalate (CaOx) raphide crystal formation, and structural features related to regulation of crystal formation, were studied in Lemna minor fronds using physiological and microscopy techniques. •  Specialized crystal-forming cells (crystal idioblasts) increased in number and size; CaOx, but not soluble oxalate, increased in response to increasing calcium in the growth medium. Size and number of idioblasts had a distinct upper limit.