Bone mineral density in Palestinian patients with end-stage renal disease and the related clinical and biochemical factors: Cross-sectional study.

Introduction: End-Stage Renal Disease (ESRD) is the ultimate result of chronic kidney disease (CKD). In Palestine, the prevalence of ESRD was 240.3 PMP which is comparable with the nearby countries.

Elective egg freezing: what is the vision of women around the globe?

Aim: The interest in oocyte cryopreservation (OC) for nonmedically indicated reasons is increasing. Knowing women's beliefs and knowledge from various geographic regions could help providers to understand the similarities and differences that could facilitate proper counseling.

Materials & Methods: Articles about social egg freezing published over the past 18 years were extracted from the literature.

Physicians' attitudes towards using elective oocyte cryopreservation to accommodate the demands of their career.

Purpose: Among medical professionals, there appears to be a significant lack of knowledge about oocyte cryopreservation. Medical professionals may be potential candidates for elective oocyte cryopreservation due to the demands and commitments of medical training. There is a paucity of data on this topic among medical professionals.

Morbid obesity and outcome of ectopic pregnancy following capped single-dose regimen methotrexate.

Purpose: Evaluate whether morbid obesity influenced resolution, number of doses or ultimately surgical management of tubal ectopic pregnancy (TEP) when treated with single-dose regimen methotrexate (SDR-MTX) capped at 100 mg.

Methods: Retrospective cohort study of patients with a diagnosis of TEP who underwent MTX treatment from 2000 to 2013. Patients were excluded if initial β-hCG <1000 mIU/mL, did not have β-hCG follow-up or were not treated with SDR-MTX.

The effect of paternal age on outcome in assisted reproductive technology using the ovum donation model.

Objective: To determine the effect of paternal age (PA) on implantation and live birth rates in an ovum donation program.

Design: Retrospective study.

Methods: A total of 237 ovum donor cycles were reviewed.

Misdiagnosis of cervical ectopic pregnancy.

Purpose: To determine the presenting symptoms as well as the frequency and reasons for the delayed diagnosis of cervical ectopic pregnancy (CEP) in order to increase detection and prevent treatment delay.

Methods: Retrospective case series of 15 women treated for CEP from January 1997 through December 2008 at a university teaching hospital.

Results: Fifteen patients were treated for CEP during the study period.

Conservative management of cervical ectopic pregnancy: utility of uterine artery embolization.

Objective: To evaluate the use of uterine artery embolization (UAE) in conjunction with methotrexate in the conservative treatment of cervical ectopic pregnancy (CEP).

Design: Case series.

Setting: Tertiary-care university hospital.

The role of hysteroscopic biopsy in obtaining specimens for cytogenetic evaluation in missed abortion prior to suction dilatation and curettage.

Aim: To estimate whether hysteroscopic-guided biopsy of gestational sac(s) in first trimester missed abortion increases the sensitivity of detecting aneuploidy compared to washing and careful specimen collection after suction dilatation and curettage (D&C).

Materials And Methods: Thirty-five patients with first trimester missed abortion of which 25 underwent 29 suction D&Cs and 10 underwent hysteroscopic-guided biopsy of 12 gestational sacs prior to suction D&C. The karyotype of products of conception specimens were analyzed by G-banding techniques.

Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells.

Benzo(a)pyrene (BaP), a cigarette smoke component, is metabolized to diol esters (BPDE) that bind to DNA and form mutagenic BPDE-DNA adducts. BaP activates stress enzymes including stress-activated protein kinase/jun kinase (MAPK8/9) in embryos, AMP-activated protein kinase alpha1/2 subunits (PRKAA1/2) in somatic cells, and inhibits the proliferation of trophoblast cell lineages. The loss of transcription factor inhibitor of differentiation (ID)2 is required for the initial differentiation of mouse trophoblast stem cells (TSC) in implanting mouse embryo to produce the first placental hormone, chorionic sommatomammotropin (CSH)1.

Placement of a permanent birth control device at a university medical center.

Objective: To determine the Essure placement failure rate and analyze factors associated with failure in an urban, nonstudy population at a university medical center.

Study Design: A retrospective study was conducted of women who underwent attempted Essure hysteroscopic sterilization at the Detroit Medical Center (DMC) from January 1, 2003, to June 30, 2007.

Results: There were 316 Essure procedures attempted at the DMC from January 2003 through June 2007.

Ureterocele misdiagnosed as pelvic inflammatory disease in an adolescent.

Background: Acute pelvic pain in reproductive-aged women presents a diagnostic challenge. In the case that follows, we report the management of a patient initially misdiagnosed with pelvic inflammatory disease.

Case: A 14-year-old nulligravida who presented with acute pelvic pain was diagnosed with pelvic inflammatory disease and possible tuboovarian abscess.

Trends in sterilization since the introduction of Essure hysteroscopic sterilization.

Study Objective: To investigate trends in sterilization in women at the Detroit Medical Center, Michigan (DMC), since the introduction of Essure hysteroscopic sterilization.

Design: Retrospective study (Canadian Task Force classification II-2).

Setting: Outpatient surgery center and university teaching hospitals.

Post-Essure hysterosalpingography compliance in a clinic population.

Study Objective: To determine the follow-up rate for post-Essure hysterosalpingography (HSG) in a non-study, general clinic population in an urban environment.

Design: Retrospective chart review (Canadian Task Force classification II-2).

Setting: University teaching hospital.

Karyotyping twins in early pregnancy loss: a novel approach of obtaining specimens to avoid maternal contamination.

Objective: To test for chromosomal abnormalities in a missed abortion involving a twin gestation.

Design: Case report.

Setting: University-based infertility practice.

Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity.

Background And Objectives: Arsenic trioxide (ATO) is an effective treatment for acute promyelocytic leukemia (APL) and potentially for human T-cell leukemia virus type I (HTLV-I) associated adult T-cell leukemia/lymphoma (ATL). Many cytotoxic drugs induce apoptosis through the generation and accumulation of the sphingolipid breakdown product, ceramide, a coordinator of the cellular response to stress. We, therefore, investigated the contribution of ceramide to the mechanism of action of ATO in APL and ATL.

Massive subchorionic hematomas following thrombolytic therapy in pregnancy.

Background: Medical therapy for thrombosed valve in pregnancy has become an acceptable alternative to surgery, especially in hemodynamically compromised patients. Placental changes after thrombolytic therapy have rarely been reported.

Cases: Sonograms were done within 24 hours after administration of thrombolytic agents at 15 and 26 weeks of gestation, respectively, in 2 women whose pregnancies were complicated with thrombosis of prosthetic mitral valves.

Sequential use of thrombolytic agents for thrombosed mitral valve prosthesis during pregnancy.

Thrombolytic therapy has gained popularity as an alternative to surgery in the treatment of prosthetic heart valve thrombosis. We report on the sequential use of streptokinase followed by recombinant tissue type plasminogen activator (rt-PA) for the treatment of a thrombosed prosthetic mitral valve in a pregnant woman at 26 weeks of gestation. Although thrombolysis was unsuccessful, the patient carried till 34 weeks of gestation and delivered by cesarean section a live newborn with an uneventful postpartum course.