Publications by authors named "Mayuyo Mori-Uchino"
Article Synopsis
- Co-infections with multiple HPV genotypes in Japan are linked to increased sexual activity, with a study analyzing data from 8,128 women under 40 diagnosed with cervical abnormalities from 2012 to 2023.
- Significant declines in multiple HPV infections were observed across different categories of cervical disease (CIN1/2, CIN3/AIS, ICC) over the past decade.
- The study suggests that this decline may correlate with reduced sexual activity among Japanese women, as indicated by a survey of sexual behavior showing a strong link between the number of sexual partners and increased HPV infections.
Real-world data on venous thromboembolism (VTE) in Japanese patients with gynecological cancer are lacking. The GOTIC-VTE trial aimed to evaluate the frequency of VTE-associated events and risk factors at the time of cancer diagnosis and during 1-year follow-up. From July 2017 to February 2019, patients with endometrial, cervical, ovarian, tubal, or peritoneal cancer who underwent VTE screening within 2 months before registration, were enrolled.
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- Ovarian clear cell carcinoma (OCCC) patients frequently experience thrombosis, which has been linked to worse prognoses in cancer generally, but its specific impact on OCCC outcomes was unclear.
- A study of 115 OCCC patients revealed that thrombosis occurred in 12.5% of early-stage and 42.8% of late-stage patients, significantly increasing the risk of poorer survival rates (e.g., 5-year progression-free survival was 20.6% for early-stage patients with thrombosis compared to 91.8% without).
- The findings indicate that thrombosis is more common in advanced OCCC stages and correlates with significantly worse prognosis across all stages, highlighting the need for closer monitoring
Article Synopsis
- Hypersensitivity reactions (HSRs) to chemotherapy, particularly carboplatin, are significant adverse events that can affect cancer drug therapy, prompting a study on desensitization methods.
- The study included 136 patients with gynecological cancers undergoing carboplatin desensitization therapy between 2016 and 2020, tracking their treatment responses and HSR symptoms.
- Findings revealed a 75% success rate for desensitization, with common symptoms like erythema and itching, while no deaths occurred during the study, indicating the need for awareness of potential HSRs.
Article Synopsis
- The study aims to enhance the detection of endometrial lesions using hysteroscopy by identifying key characteristics that indicate malignancy.
- A retrospective analysis of hysteroscopy videos from 250 patients revealed that specific features like desquamation and atypical vessels were strong indicators of endometrial cancer, showing high sensitivity and specificity in diagnosis.
- Although the findings demonstrate promising predictive ability, further studies with larger sample sizes are necessary to improve diagnostic accuracy in detecting endometrial malignancies.
Article Synopsis
- The GOTIC-VTE trial in Japan aimed to assess the effectiveness of continuous anticoagulant therapy for preventing postoperative pulmonary embolism (PE) in gynecologic cancer patients with asymptomatic venous thromboembolism (VTE).
- The study enrolled 99 patients and focused on the incidence of symptomatic PE and other related events over 28 days post-surgery, with no PE incidents reported.
- The results suggest that the approach used in the trial greatly reduces the risk of postoperative PE, demonstrating the effectiveness of consistent anticoagulant management in these patients.
Article Synopsis
- - This study investigates the unique metabolic characteristics of ovarian clear cell carcinoma (CCC) by comparing it to normal tissues, specifically focusing on increased glutathione synthesis and its role in the cancer's development.
- - Evidence shows that CCC cells experience ferroptosis due to high levels of intracellular iron and lipid peroxides, which lead to cell death when glutathione synthesis is inhibited.
- - The use of a fluorescent imaging probe (gGlu-HMRG) successfully highlights differences in glutathione metabolism, displaying strong fluorescent signals in CCC tumor tissues, potentially aiding in distinguishing cancerous tissues from normal ones.
The first prophylactic vaccine against human papillomavirus (HPV) 16 and HPV18 was licensed in Japan in 2009. HPV vaccine effectiveness against high-grade cervical lesions has been demonstrated among young Japanese women, but evidence of its effects on invasive cervical cancer (ICC) is lacking. Using data from two different cancer registries, we compared recent trends of new ICC cases by age group using Poisson regression analysis.
View Article and Find Full Text PDFBackground: Management of a bladder tumor during pregnancy is an uncommon clinical situation. Leiomyosarcoma of the urinary bladder is a rare histological type of bladder tumor and a rare secondary cancer in survivors of retinoblastoma (RB). However, there has been no report of RB-associated bladder leiomyosarcoma during pregnancy.
View Article and Find Full Text PDFBackground: Small cell carcinoma of the uterine cervix (SCCC) is a rare and highly malignant human papillomavirus (HPV)-associated cancer in which human genes related to the integration site can serve as a target for precision medicine. The aim of our study was to establish a workflow for precision medicine of HPV-associated cancer using patient-derived organoid.
Methods: Organoid was established from the biopsy of a patient diagnosed with HPV18-positive SCCC.
The cellular origins of cervical cancer and the histological differentiation of human papillomavirus (HPV)-infected cells remain unexplained. To gain new insights into the carcinogenesis and histological differentiation of HPV-associated cervical cancer, we focused on cervical cancer with mixed histological types. We conducted genomic and transcriptomic analyses of cervical cancers with mixed histological types.
View Article and Find Full Text PDFUterine sarcomas have very poor prognoses and are sometimes difficult to distinguish from uterine leiomyomas on preoperative examinations. Herein, we investigated whether deep neural network (DNN) models can improve the accuracy of preoperative MRI-based diagnosis in patients with uterine sarcomas. Fifteen sequences of MRI for patients (uterine sarcoma group: n = 63; uterine leiomyoma: n = 200) were used to train the models.
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- SETD8 is a histone methyltransferase linked to endometrial cancer, influencing cell proliferation and apoptosis by modifying histone H4 at lysine 20 and affecting the p53 signaling pathway.
- The study found that SETD8 expression is significantly higher in endometrial cancer tissues and that reducing SETD8 through siRNAs or inhibitors suppresses cancer cell growth and encourages cell death.
- Key genes related to apoptosis, including KIAA1324 and TP73, were identified as being regulated by SETD8, indicating their importance in cancer progression and prognosis.
Article Synopsis
- Homologous recombination (HR) is crucial for repairing DNA double-strand breaks and is linked to cancer, with HR deficiency being a target for therapy.
- A novel HR factor, MED1, was identified as a binding partner of BRCA1, enhancing BRCA1's transcription ability and participating in DNA damage response processes.
- MED1 depletion led to impaired HR activity and increased accumulation of harmful R-loops, indicating its important role in regulating the HR pathway and managing R-loop processing.
Article Synopsis
- The study evaluated the effectiveness of the manual vacuum aspiration (MVA) system for endometrial sampling compared to traditional methods like fractional curettage and total curettage.
- The MVA group showed significantly better sample quality than the fractional curettage group, especially when the endometrial thickness was ≥10 mm.
- The researchers concluded that MVA could be a safer and more effective alternative for endometrial sampling.
Histone modification is the key epigenetic mechanism that regulates gene expression. Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that catalyzes dimethylation of histone H3 (H3R17) at arginine 17. Lately, it has been suggested that CARM1 is associated with human carcinogenesis, and the CARM1-selective inhibitor, TP-064, has been shown to be a potential therapeutic agent for multiple myeloma.
View Article and Find Full Text PDFIn 5% of female patients with malignant melanoma (MM), MM develops from the genital tract. MM of the cervix is particularly rare. In the present case report, a 73-year-old woman with stage ⅢC cervical MM underwent modified radical hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection.
View Article and Find Full Text PDFWe encountered HPV6-positive cervical papillary squamous cancer (PSCC) that was difficult to diagnose. The case was initially diagnosed and treated for condyloma. To the best of our knowledge, this is the first report of HPV6 infection in PSCC.
View Article and Find Full Text PDFEndometrial stromal sarcoma is a rare uterine mesenchymal neoplasm, and extrauterine endometrial stromal sarcoma is even rarer, with a limited number of case reports. In the present report, we present a case of low-grade extrauterine endometrial stromal sarcoma originating from the mesentery in a 49-year-old woman, without endometrial stromal sarcoma in the uterus or evidence of endometriosis. The tumor was diagnosed using recombination of the gene by fluorescence in situ hybridization.
View Article and Find Full Text PDFThe histone methyltransferase SETD8, which methylates the lysine 20 of histone H4 (H4K20), is reportedly involved in human carcinogenesis along with nonhistone proteins such as p53. However, its expression profiles and functions in the context of high-grade serous ovarian carcinoma (HGSOC) are still unknown. The purpose of this study was to investigate the role of SETD8 in HGSOC.
View Article and Find Full Text PDFA diagnostic biopsy for endometrial cancer is performed via dilation and curettage (D&C). However, D&C may miss endometrial cancer lesions due to of its 'blind' approach. Hysteroscopy is a useful method that can be used to detect endometrial cancer lesions.
View Article and Find Full Text PDFBackground: Soluble Fms-like tyrosine kinase-1 (sFLT1) as an anti-angiogenic factor is abundantly expressed in placental trophoblasts. Choriocarcinoma, a malignant tumor derived from trophoblasts, is known to be highly angiogenic and metastatic. However, the molecular mechanism underlying angiogenesis in choriocarcinoma pathogenesis remains unclear.
View Article and Find Full Text PDFIntroduction: PI3K pathway signaling has received attention as a molecular target in clear cell ovarian carcinoma (CCOC). MDM2 is one of the AKT effectors in the PI3K pathway, which binds to and degrades p53. In this study, we aimed to clarify the prognostic significance of PIK3CA and MDM2 expression, and potential therapeutic effect of a dual inhibition of the PI3K pathway and MDM2.
View Article and Find Full Text PDFThe programmed cell death 1/programmed cell death 1 ligand 1 pathway was successfully targeted in cancer immunotherapy. Elevated interleukin-17 (IL-17), which is known in autoimmune diseases, has recently been recognized in cancer patients. We investigated the role of IL-17 in the regulation of expression of programmed cell death 1 ligand 1 in ovarian cancer by evaluating changes in the number of IL-17-producing cluster of differentiation 4 helper T cells (Th17) and γδT cells (γδT17) in PBMC of 52 gynecological cancer patients (including 30 ovarian cancer patients) and 18 healthy controls.
View Article and Find Full Text PDFBackground: Wolf-Hirschhorn syndrome candidate gene-1 (WHSC1), a histone methyltransferase, has been found to be upregulated and its expression to be correlated with expression of enhancer of zeste homolog 2 (EZH2) in several cancers. In this study, we evaluated the role of WHSC1 and its therapeutic significance in ovarian clear cell carcinoma (OCCC).
Methods: First, we analyzed WHSC1 expression by quantitative PCR and immunohistochemistry using 23 clinical OCCC specimens.