The role of Piezo1 mechanotransduction in high-grade serous ovarian cancer: Insights from an in vitro model of collective detachment.

Slowing peritoneal spread in high-grade serous ovarian cancer (HGSOC) would improve patient prognosis and quality of life. HGSOC spreads when single cells and spheroids detach, float through the peritoneal fluid and take over new sites, with spheroids thought to be more aggressive than single cells. Using our in vitro model of spheroid collective detachment, we determine that increased substrate stiffness led to the detachment of more spheroids.

Overview on recent advances of magnetic metal-organic framework (MMOF) composites in removal of heavy metals from aqueous system.

Developing a novel, simple, and cost-effective analytical technique with high enrichment capacity and selectivity is crucial for environmental monitoring and remediation. Metal-organic frameworks (MOFs) are porous coordination polymers that are self-assembly synthesized from organic linkers and inorganic metal ions/metal clusters. Magnetic metal-organic framework (MMOF) composites are promising candidate among the new-generation sorbent materials available for magnetic solid-phase extraction (MSPE) of environmental contaminants due to their superparamagnetism properties, high crystallinity, permanent porosity, ultrahigh specific surface area, adaptable pore shape/sizes, tunable functionality, designable framework topology, rapid and ultrahigh adsorption capacity, and reusability.

Self-assembly of multiscale anisotropic hydrogels through interfacial polyionic complexation.

Polysaccharides are explored for various tissue engineering applications due to their inherent cytocompatibility and ability to form bulk hydrogels. However, bulk hydrogels offer poor control over their microarchitecture and multiscale hierarchy, parameters important to recreate extracellular matrix-mimetic microenvironment. Here, we developed a versatile platform technology to self-assemble oppositely charged polysaccharides into multiscale fibrous hydrogels with controlled anisotropic microarchitecture.