Publications by authors named "Mayur Dhangar"
Linezolid, a widely used oxazolidinone antibiotic, exhibits potent activity against resistant bacterial infections but is associated with serotonergic toxicity, primarily due to its inhibition of monoamine oxidase (MAO). MAOs, consisting of MAO-A and MAO-B isoforms, play crucial roles in neurotransmitter metabolism, with implications for neurodegenerative disorders like Parkinson's and Alzheimer's diseases. This study aims to optimize Linezolid's structure to transform it into a selective MAO-B inhibitor.
View Article and Find Full Text PDFThe USFDA granted regular approval to Osimertinib (AZD9291) on March 2017, for treating individuals with metastatic Non-Small Cell Lung Cancer having EGFR T790M mutation. Clinically, Osimertinib stands at the forefront for the treatment of patients with Non-Small Cell Lung Cancer. Osimertinib forms a covalent bond with the Cys797 residue and predominantly spares binding to WT-EGFR, thereby reducing toxicity and enabling the administration of doses that effectively inhibit T790M.
View Article and Find Full Text PDFArticle Synopsis
- Multidrug-resistant tuberculosis (MDR-TB) strains have made many existing anti-TB drugs ineffective, creating a need for new treatment options.
- The Filament Forming Temperature Sensitive Gene Z (FtsZ) is crucial for cell division in Mycobacterium tuberculosis (Mtb) by forming a key structure that coordinates cell division; when disrupted, the bacteria cannot divide properly.
- This review highlights FtsZ as a promising target for new anti-tuberculosis drugs and discusses its role in Mtb cell division and the potential of various inhibitors that could impede its function to treat tuberculosis more effectively.