Publications by authors named "Mayur Dalasaniya"
Article Synopsis
- Aurora kinases A and B are vital for cell division, and their abnormal activity can lead to cancer; thus, inhibitors targeting these kinases are being researched as potential cancer treatments.
- The study highlights a new compound, 6k, which showed strong cytotoxic effects against HeLa and HepG2 cancer cells, specifically inhibiting Aurora kinases A and B at very low concentrations.
- 6k was found to induce cell cycle arrest at the G2/M phase, increase signs of apoptosis, and demonstrated promising drug-like properties, suggesting it may be a candidate for further testing in cancer therapy.
Phosphatidylinositide-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) have recently been identified as potential cancer targets. In our work, a new family of quinoline analogues was designed, developed, and evaluated as dual inhibitors of PI3Kδ/mTOR. The preliminary biological activity analysis led to the discovery of the lead compounds 5h and 5e.
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