Comparative genome analysis of test algal strain NIVA-CHL1 (Raphidocelis subcapitata) maintained in microalgal culture collections worldwide.

Raphidocelis subcapitata is one of the most frequently used species for algal growth inhibition tests. Accordingly, many microalgal culture collections worldwide maintain R. subcapitata for distribution to users.

Topochemical cross-linking of the [Hf2N2] layers with sulfur in α-HfNBr.

α-HfNBr (space group Pmmn) isostructural with FeOCl consists of orthorhombic [Hf2N2] layers sandwiched by bromide layers. By the reaction with Na2S at 750 °C in a sealed glass tube, the α-type [Hf2N2] layers are topochemically cross-linked with sulfur to form α-Hf2N2S with a mutual shift of the layers in the ab plane by (a/2 + b/2) to crystallize in space group Immm and the lattice parameters a = 4.1422(1), b = 3.

High drug loading self-microemulsifying/micelle formulation: design by high-throughput formulation screening system and in vivo evaluation.

Purpose: To design a high drug loading formulation of self-microemulsifying/micelle system.

Methods: A poorly-soluble model drug (CH5137291), 8 hydrophilic surfactants (HS), 10 lipophilic surfactants (LS), 5 oils, and PEG400 were used. A high loading formulation was designed by a following stepwise approach using a high-throughput formulation screening (HTFS) system: (1) an oil/solvent was selected by solubility of the drug; (2) a suitable HS for highly loading was selected by the screenings of emulsion/micelle size and phase stability in binary systems (HS, oil/solvent) with increasing loading levels; (3) a LS that formed a broad SMEDDS/micelle area on a phase diagram containing the HS and oil/solvent was selected by the same screenings; (4) an optimized formulation was selected by evaluating the loading capacity of the crystalline drug.

[Simple preprocessing method for multi-determination of 235 pesticide residues in cooked ingredients of foods by GC/MS and LC/MS/MS].

A simple preprocessing method was developed for multiresidue determination of pesticides in processed agricultural products. Residues were extracted from homogenized samples with acetonitrile in a glass centrifuge tube, followed by salting-out and partitioning with n-hexane. Co-extractives were removed by means of mini-column clean up.

[A case of multicentric bronchio-alveolar cell carcinomas with mild improvement during clinical course].

It is very important for clinicians to recognize that some lung cancers, especially among the bronchiolo-alveolar cell carcinomas (BAC), rarely show mild improvement in opacity during the clinical course. We would like to present a 63-year-old woman who demonstrated very unusual exacerbation and improvement in lung opacity during 7 years of follows up. The abnormal chest shadows pointed out in an initial screening checkup and in a following chest CT presented 4 nodules in both lung fields; 2 of them appeared to have cavities.