Publications by authors named "Mayumi Tsuji"
Article Synopsis
- - The study investigates the relationship between workplace stressors and the risk of developing Long COVID among Japanese workers, aiming to enhance understanding and inform workplace management.
- - Researchers analyzed survey data from 1,539 participants, focusing on factors like job demands, job control, and social support, with 248 participants reporting Long COVID symptoms that lasted over two months.
- - Results indicate that high job demands, poor job control, and lack of support from supervisors and co-workers increase the likelihood of Long COVID, suggesting that managing workplace stress could help prevent its development.
Article Synopsis
- The study aimed to investigate why pregnant women with glucose intolerance often have large infants, focusing on amino and fatty acid transport in the placenta, beyond just glucose transport.
- Researchers analyzed postpartum placental tissues from 101 eligible deliveries, finding higher expression levels of certain transporters (LAT1 and placenta-FABPpm) in women with glucose intolerance compared to those without.
- The results suggest that, despite controlled blood sugar levels, managing other nutrients like amino acids and fatty acids in glucose-intolerant pregnancies is crucial for fetal growth.
The coronavirus disease 2019 (COVID-19) pandemic forced people to change their lifestyles. We examined dietary differences by job type and industry among workers during the pandemic. This cross-sectional study was conducted using data an internet survey.
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- Natural killer group 2 member D ligands (NKG2DLs) in cancer cells can either activate immune responses or help tumors evade them, depending on their levels in the cells.
- In pancreatic cancer cells (PANC-1), soluble MICB (sMICB) is found in the culture supernatant, which may saturate NKG2D T cells and inhibit their activation by membrane-bound MICB (mMICB).
- Inhibiting the enzyme ADAM17, which contributes to the shedding of MICB, can help maintain mMICB expression and enhance NKG2D T cell activation, demonstrating a potential strategy to improve anti-tumor immune responses.
This study evaluated trends in the implementation of workplace measures against COVID-19 by Japanese companies. We conducted a prospective cohort study, using data from December 2020 and December 2021, with 13,419 respondents participating in the follow-up survey. We evaluated nine workplace measures against COVID-19 (e.
View Article and Find Full Text PDFObjective: The work environment during work from home (WFH) may have a negative impact on workers' health. We investigated the effects of the physical work environment during WFH on sleep.
Methods: We conducted a 1-year cohort study of 2099 Japanese WFH workers.
To examine whether patterns, such as the timings of onset or recovery from sleep disturbance, are associated with later developmental problems, including autism spectrum disorder (ASD). Mothers participating in the Japan Environment and Children's Study with a child aged 3 years were included in the analyses. Children were assessed for short sleep and frequent awakenings at 1 month, 6 months, and 1 year of age.
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- The study aimed to explore how telecommuting affects sleep quality based on whether workers' telecommuting preferences match their actual frequency of working from home.
- Researchers collected survey data from over 33,000 Japanese workers, focusing on 9,425 who answered follow-up questions, to assess their sleep quality using the Athens Insomnia Scale.
- Results indicated that workers who preferred telecommuting experienced a significantly higher risk of insomnia if they telecommuted less frequently, particularly those telecommuting less than once a week.
Occupational exposure to welding fumes constitutes a serious health concern. Although the effects of fumes on the respiratory tract have been investigated, few apparent reports were published on their effects on the skin. The purpose of this study was to investigate the effects of exposure to welding fumes on skin cells, focusing on interleukin-24 (IL-24), a cytokine involved in the pathophysiology of skin conditions, such as atopic dermatitis and psoriasis.
View Article and Find Full Text PDFAmyloid β-peptide (Aβ) synthesis and deposition are the primary factors underlying the pathophysiology of Alzheimer's disease (AD). Aβ oligomer (Aβo) exerts its neurotoxic effects by inducing oxidative stress and lesions by adhering to cellular membranes. Though several antidepressants have been investigated as neuroprotective agents in AD, a detailed comparison of their neuroprotection against Aβo-induced neurotoxicity is lacking.
View Article and Find Full Text PDFThe low response rate of immune checkpoint inhibitors (ICIs) is a challenge. The efficacy of ICIs is influenced by the tumour microenvironment, which is controlled by the gut microbiota. In particular, intestinal bacteria and their metabolites, such as short chain fatty acids (SCFAs), are important regulators of cancer immunity; however, our knowledge on the effects of individual SCFAs remains limited.
View Article and Find Full Text PDFBackground: Lifelong health is dependent on prenatal growth and development, influenced by the placental intrauterine environment. Charged with dual functions--exchange of oxygen and nutrients as well as a barrier against toxins--the placenta itself is susceptible to environmental exposure to heavy metals.
Objective: To examine the use of placenta weight as a biomarker for heavy metal exposure using a large Japanese cohort of pregnant women.
Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
Oral Maxillofac Surg
September 2024
Objective: This study evaluated the efficacy of Valeriana officinalis L. and Passiflora incarnata L. to control anxiety, surgical discomfort, and changes in vital signs of patients undergoing extraction of two unilateral third molars.
View Article and Find Full Text PDFBackground: The impact of parent-childbearing age on child development at 36 months of age is controversial.
Aims: We used data from a large cohort study with multiple imputation and mediation analyses of variables.
Methods And Procedures: A total of 72,606 parent-child pairs from the Japan Environment and Children's Study were included in the study.
Article Synopsis
- A study in Japan examined how socioeconomic factors, particularly occupation, affect the risk of coronary heart disease (CHD) during the COVID-19 pandemic, using data from 17,640 workers.
- Upper-level nonmanual workers (like managers and professionals) had a higher incidence of CHD (2.3%) compared to other workers (1.7%), especially among younger individuals aged 20-49.
- The research found that remote work contributed to a 32% disparity in CHD risk, suggesting that it plays a significant role in moderating health risks for upper-level workers in Japan, contrary to patterns seen in Western countries.
Article Synopsis
- Presenteeism negatively impacts workers' health and quality of life, increasing the risk of job resignations and unemployment, especially in the context of the COVID-19 pandemic.
- A study involving over 27,000 Japanese workers found that those with higher work functioning impairment, as measured by the Work Functioning Impairment Scale, faced significantly greater odds of leaving their jobs for health-related reasons.
- There is a need for management strategies to support employees experiencing work functioning impairment to help mitigate their employment disadvantages.
Article Synopsis
- Researchers explored the relationship between intestinal bacteria and postoperative recurrence in esophageal cancer patients after preoperative chemotherapy.
- They used 16S rRNA metagenome sequencing and machine learning analysis to identify specific bacteria linked to cancer recurrence.
- The study highlighted Butyricimonas and Actinomyces as potentially significant biomarkers, with Butyricimonas suggested as a factor in postoperative recurrence, warranting further investigation into their immune regulation roles.
Article Synopsis
- Immune checkpoint inhibitors, like PD-1 inhibitors, have changed cancer treatment, but only 10%-30% of patients with solid tumors respond well to these therapies.
- This study investigated how the occupancy of the PD-1 receptor in different T-cell populations, particularly effector regulatory T cells (eTregs), relates to patient outcomes and adverse effects in people treated with the drug nivolumab.
- Findings showed that lower PD-1 occupancy on eTregs was linked to better clinical outcomes and lower mortality, suggesting that managing PD-1 signaling in these cells could enhance the effectiveness of cancer therapies.
Objective: Discriminatory treatment against those with emerging infection is a long-standing problem. The present study investigates whether workers infected or in close contact with COVID-19 were susceptible to workplace mistreatment during the pandemic in Japan.
Methods: This Internet-based cross-sectional study analyzed a total of 18,170 workers aged 20 to 60 years in Japan in December 2020.
Purpose: This study examines workplace support and resilience's influence on psychological distress in Japanese employees.
Method: A 1-year prospective online cohort study was conducted. Logistic regression analyzed prevalence odds ratios and 95% confidence intervals for psychological distress.
Article Synopsis
- Bisphenol A diglycidyl ether (BADGE) and Bisphenol F diglycidyl ether (BFDGE) are chemicals found in medical devices like syringes and catheters, raising concerns about their harmful effects on infants.
- A study measured the serum levels of these compounds and their derivatives in ten infants from the neonatal intensive care unit (NICU) at 1-2 months and 7 months of age, using advanced mass spectrometry techniques.
- Results showed that all infants had detectable levels of BADGE·2HO, with one infant on invasive ventilation having particularly high concentrations, highlighting the need for further research on the source of exposure and potential developmental impacts on infants.
Background: The impact of COVID-19 infection on workers' work function persists even after the acute phase of the infection. We studied this phenomenon in Japanese workers.
Methods: We conducted a one-year prospective cohort study online, starting with a baseline survey in December 2020.
Article Synopsis
- The study examines the potential for non-classical monocytes (NCMs) to improve the effectiveness of immune checkpoint inhibitors (ICIs) in colon cancer, which typically have a low response rate.
- Using a mouse model with colon cancer, researchers treated the mice with a combination of ICIs and NCMs and found that this combination was more effective than ICIs alone.
- The results indicate that while NCMs enhance the response to ICIs, they do not work effectively on their own; further research will explore how this works and its potential clinical applications.
Article Synopsis
- - The study aimed to explore the link between COVID-19 infection and psychological distress among people in Japan.
- - Researchers analyzed data from 14,901 participants, focusing on how having had COVID-19 affected their mental health.
- - The findings indicated a connection between COVID-19 infection and psychological distress, which was significantly influenced by feelings of being treated unfairly.