Publications by authors named "Mayumi Sugawara"
Article Synopsis
- Ferroptosis is a form of cell death linked to iron and lipid damage, gaining interest for its potential in cancer treatment and toxicity studies.
- The enzyme GPx4, which contains selenium, is a key regulator of ferroptosis, but it's difficult to study accurately due to various factors in lab settings.
- The study reveals that selenium levels in fetal bovine serum (FBS) affect the expression of selenium proteins like GPx4, impacting cell resistance to ferroptosis, emphasizing the need for standardized selenium content in experiments.
Background: Skills Training in Affective and Interpersonal Regulation (STAIR) Narrative Therapy (SNT) has shown efficacy in alleviating symptoms of posttraumatic stress disorder (PTSD) and improving emotion regulation and interpersonal skills among individuals with complex trauma, such as childhood abuse. Although this therapy is expected to be effective for patients with complex PTSD (CPTSD), no study has directly assessed diagnostic and symptom outcomes. Moreover, the potential of therapy to achieve good outcomes in non-Western countries remains unclear.
View Article and Find Full Text PDFObjective: Autoimmune cerebellar ataxias were recently reported to be treatable. However, the proportion of patients with cortical cerebellar atrophy of unknown etiology with autoimmune-associated cerebellar ataxia and the actual effectiveness of immunotherapy in these diseases remain unknown.
Methods: We measured the level of autoantibodies (including anti-gliadin antibody, anti-glutamic acid decarboxylase (GAD) antibody, and anti-thyroid antibody) in 58 Japanese patients with cerebellar ataxia, excluding those with multiple system atrophy, hereditary spinocerebellar ataxia, cancer, or those who were receiving phenytoin, and the efficacy of immunotherapy was assessed.