Publications by authors named "Mayuko Tonai"
Article Synopsis
- The study aimed to evaluate whether mechanical left ventricular unloading could lower mortality rates in patients with cardiogenic shock who were receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO).
- A meta-analysis included data from two randomized controlled trials and eleven propensity score-matched studies, involving a total of 9,858 patients, and found that mechanical unloading significantly decreased mortality rates (RR, 0.89; P = 0.0001).
- While mechanical unloading showed benefits in reducing mortality and improving outcomes, it also resulted in increased risks of major bleeding and hemolysis, indicating a need for careful consideration in clinical practice.
Article Synopsis
- Tracheal intubation is commonly performed on critically ill patients, and this meta-analysis explored whether ketamine, due to its favorable cardiovascular effects, reduces mortality during this procedure compared to other agents.
- The research evaluated data from various studies, focusing on mortality rates and other health metrics, finding that ketamine had an 83.2% probability of reducing mortality compared to etomidate, though the difference wasn’t statistically significant.
- Overall, while ketamine is likely safe with comparable outcomes to etomidate based on the data, the absence of significant improvements in secondary outcomes suggests no clear advantage in clinical use beyond standard practice.
Background: Hospital- and community-onset sepsis are significant sepsis subgroups. Japanese data comparing these subgroups are limited. This study aimed to describe the epidemiology of hospital- and community-onset sepsis in critical care units in Japan.
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