Publications by authors named "Mayuko Higuchi"
Article Synopsis
- Cystic fibrosis (CF) is caused by mutations in the CFTR gene and is more common in Caucasians than in East Asians; this study investigated CF characteristics in Japanese patients.
- The analysis of 132 CF patients revealed prevalent symptoms such as chronic lung disease (85.6%) and pancreatic insufficiency (66.7%), with a median survival age of just 25 years.
- The study found distinct CFTR variant patterns in Japanese patients compared to European ones, with specific variants like CFTR-dele16-17a-17b being more common in Japan and the F508del variant appearing in European alleles.
HCO secretion in distal airways is critical for airway mucosal defense. HCO/H transport across the apical membrane of airway surface epithelial cells was studied by measuring intracellular pH in luminally microperfused freshly dissected mice bronchioles. Functional studies demonstrated that CFTR, ENaC, Cl-HCO exchange, Na-H exchange, and Na-HCO cotransport are involved in apical HCO/H transport.
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