Publications by authors named "Mayukh Banerjea"
Article Synopsis
- Mature small non-coding RNAs (sncRNAs) that are polyadenylated but not properly processed undergo active degradation by the Rrp6p and Rrp47p proteins, without needing the core exosome or TRAMP complexes.
- Rrp6p and Rrp47p form an exosome-independent complex that specifically targets these polyadenylated sncRNAs for degradation, and a truncated version of Rrp6p can still perform this function.
- Analysis shows that most polyadenylation sites are located near the mature ends of sncRNAs, with tails typically composed of 10-15 adenylate residues, and these polyadenylated snRNAs remain functional, contributing to spliceosome assembly in
Nuclear degradation of aberrant mRNAs in Saccharomyces cerevisiae is accomplished by the nuclear exosome and its cofactors TRAMP/CTEXT. Evidence from this investigation establishes a universal role of the Nrd1p-Nab3p-Sen1p (NNS) complex in the nuclear decay of all categories of aberrant mRNAs. In agreement with this, both nrd1-1 and nrd1-2 mutations impaired the decay of all classes of aberrant messages.
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