Publications by authors named "Mayu Kiguchi"
We examined the inhibitory effects of α-linolenic acid (ALA) on the contractions of pig coronary arteries. ALA concentration-dependently inhibited the contractions elicited by U46619 and prostaglandin F without affecting those elicited by 80 mM KCl, histamine, acetylcholine, and serotonin. ALA rightward shifted the concentration-response curve of U46619, and Schild plot analysis revealed that ALA competitively antagonized U46619.
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- - The study investigates whether eicosapentaenoic acid (EPA) can reduce artery contractions caused by substances like thromboxane mimetics (U46619) and prostaglandin F (PGF), specifically by targeting the prostanoid TP receptor.
- - Results show that EPA effectively inhibited contractions in porcine basilar and coronary arteries in a dose-dependent way but had no impact on contractions triggered by high potassium levels (KCl).
- - Additionally, EPA reduced calcium signaling related to the TP receptor in human cells but only had minimal effects related to the FP receptor, suggesting that the inhibition of TP receptors is a key mechanism for EPA's ability to relax these artery contractions.