Publications by authors named "Mayu Isumi"
Poly(ADP-ribose) polymerase (Parp)-1 catalyzes polyADP-ribosylation using NAD and is involved in the DNA damage response, genome stability, and transcription. In this study, we demonstrated that aged mouse incisors showed more frequent dental dysplasia in both ICR/129Sv mixed background and C57BL/6 strain compared to aged incisors, suggesting that Parp-1 deficiency could be involved in development of dental dysplasia at an advanced age. Computed tomography images confirmed that dental dysplasia was observed at significantly higher incidences in mice.
View Article and Find Full Text PDFDevelopment of renal failure in PargParp-1 null and Timm23 hypomorphic mice.
Biochem Pharmacol
September 2019
Article Synopsis
- Poly(ADP-ribose) glycohydrolase (Parg) is crucial for breaking down poly(ADP-ribose), and deleting part of its gene in mice results in embryos dying between 4.5 and 9.5 days of development.
- Introducing a deficiency in poly(ADP-ribose) polymerase-1 (Parp-1) may rescue some of the embryonic lethality, indicating Parp-1's role in the lethality of Parg embryos and highlighting the importance of Parg for embryonic growth.
- Mice with both Parg and Parp-1 deficiencies show severe kidney issues and early death, suggesting that the combined loss of these proteins can lead
Poly (ADP-ribose) polymerase family, member 1 (Parp1) has pleiotropic and disparate functions in multiple cellular signaling pathways through post-translational protein modification. It contributes to the regulation of various cellular processes, including DNA damage repair, cell death, and cell differentiation, genetically or epigenetically. Meanwhile, the functions of Parp1 in intercellular signaling remain to be established.
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