Synergistic effect of SrTiO/CuFeO/MIL-101(Co) as a MOF composite under Gamma-rays for antimicrobial potential versus bacteria and pathogenic fungi.

The primary emphasis of this study was on the innovative and scientifically valuable hydrothermal synthesis of MIL-101(Co) as a metal-organic framework (MOF) material. Subsequently, the CuFeO was incorporated into the MOF by a reduction-precipitation technique. The SrTiO/CuFeO/MIL-101(Co) composite was synthesized by using hydrothermal in situ growth process.

Study on Acute Toxicity of Amiodarone New Complexes With Cyclodextrin.

Amiodarone low solubility and high permeability is the limiting step for its bioavailability, therefore new formulations are needed to improve the solubility of amiodarone either to increase its oral bioavailability or to reduce its toxic effects. Complexation of amiodarone with cyclodextrin results in improved dissolution rate, solubility, and allows for a more controlled drug release. We characterized the acute toxicity of a new amiodarone 2-hydroxypropyl-β-cyclodextrin complex (AMD/HP-β-CD) as powdered form and as a matrix based on Kollidon® and chitosan, administered intraperitoneally in laboratory animals.

Estimation of the Release of Amiodarone From the Pharmacokinetics of Its Active Metabolite and Correlation With Its Release.

Due to its very low water solubility and complex pharmacokinetics, a reliable point-to-point correlation of its release with its pharmacokinetics has not been achieved so far with amiodarone. The correlation of the dissolution of a drug with the pharmacokinetics of one of its metabolites was recently proposed by the authors of the article as an additional or alternative analysis to the usual correlations , mainly in the case of fast-absorbing drugs that have metabolites with a significant therapeutic effect. The model proposed by the authors considers that amiodarone has a slow dissolution, rapid absorption, and rapid metabolism, and before returning to the blood from other compartments, its pharmacokinetics is determined mainly by the kinetics of release in the intestine from the pharmaceutical formulation.