Publications by authors named "Mays Al Nofal"
Background: The brain and retina share many neuronal and vasculature characteristics. We investigated the retinal microvasculature in patients with a monogenic vasculopathy using optical coherence tomography angiography (OCTA). OCT-A is a novel precise non-invasive imaging method that may provide biomarkers suitable for diagnosis and follow-up of small vessel diseases.
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- RVCL-S is a genetic small vessel disease linked to TREX1 mutations, affecting the retina and brain, with optical coherence tomography (OCT) being used to assess retinal layer thickness as a biomarker.
- A study comparing 17 TREX1 mutation carriers to 9 controls found significantly reduced thickness in the peripapillary retinal nerve fiber layer (pRNFL) and total macular volume (TMV) among mutation carriers.
- Results suggest that OCT findings indicate retinal thinning in RVCL-S patients, even in cases with normal eye examinations, highlighting the potential for using OCT as an early diagnostic tool for vascular retinopathies.
Purpose: To generate novel, objective variables that resemble embryo quality and relate them to ongoing implantation, using multilevel imaging of single-transferred embryos.
Methods: Retrospective analysis of multilevel images of 659 day 3 single-transferred embryos. Each embryo was photographed on seven different levels, in order to measure the largest diameter of every blastomere within an embryo.