Publications by authors named "Maynard L"

Pulsed resources resulting from animal migrations represent important, transient influxes of high resource availability into recipient communities. The ability of predators to respond and exploit these large increases in background resource availability, however, may be constrained when the timing and magnitude of the resource pulse vary across years. In coastal Newfoundland, Canada, we studied aggregative responses of multiple seabird predators to the annual inshore pulse of a key forage fish species, capelin (Mallotus villosus).

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Background: Timely and economic provision of revascularisation procedures is a major healthcare need. We aimed to examine the safety and efficacy of daycase-based lower extremity endovascular revascularisation procedures in patients with peripheral artery disease.

Methods: In this systematic review and meta-analysis, we searched MEDLINE and Embase for studies from Jan 01, 2000 through Apr 01, 2024 reporting complications of lower limb endovascular revascularisation procedures with same-day discharge.

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A case study of a 9-year-old child with complex pain secondary to metastatic liver cancer, who eventually required intrathecal drug delivery (ITDD) of analgesia. Multi-modal symptom control strategies were deployed to achieve the child's and parental wishes for end-of-life care (EoLC) at home using ITDD. The following recommendations are made for nursing practice in paediatric palliative care (PPC); rigorous risk assessment, exemplary communication with the identification of a coordinating team, timely training needs assessment and the delivery of training from hospital based experts in ITDD practice, comprehensive symptom management plan and 24/7 access to specialist palliative care teams were essential for safe nursing practice.

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Practitioners in health departments, university extension programs, and nonprofit organizations working in public health face varied challenges to publishing in the peer-reviewed literature. These practitioners may lack time, support, skills, and efficacy needed for manuscript submission, which keeps them from sharing their wisdom and experience-based evidence. This exclusion can contribute to literature gaps, a failure of evidence-based practice to inform future research, reduced ability to educate partners, and delays in advancing public health practice.

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Background: Bepirovirsen is an antisense oligonucleotide that targets all hepatitis B virus (HBV) messenger RNAs and acts to decrease levels of viral proteins.

Methods: We conducted a phase 2b, randomized, investigator-unblinded trial involving participants with chronic HBV infection who were receiving or not receiving nucleoside or nucleotide analogue (NA) therapy. Participants were randomly assigned (in a 3:3:3:1 ratio) to receive weekly subcutaneous injections of bepirovirsen at a dose of 300 mg for 24 weeks (group 1), bepirovirsen at a dose of 300 mg for 12 weeks then 150 mg for 12 weeks (group 2), bepirovirsen at a dose of 300 mg for 12 weeks then placebo for 12 weeks (group 3), or placebo for 12 weeks then bepirovirsen at a dose of 300 mg for 12 weeks (group 4).

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Emerging conservation psychology literature shows that there is a strong link between positive attachment to a workplace and the performance of pro-environmental behaviors by employees at work. The present study explores the validity of a pilot survey based in previous literature that explores these constructs to determine whether a relationship between the two exists among zoo and aquarium professionals. The survey was distributed to employees of the Wildlife Conservation Society's city zoos-Prospect Park, Central Park, and Queens Zoos-during the first year of the SARS-CoV-2 pandemic.

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Conservation psychology principles can be useful for aligning organizations and scaling up conservation programs to increase impact while strategically engaging partners and communities. We can use findings and recommendations from conservation psychology to inform organizational collaborations between zoos and aquariums to maximize efficiency and coordination. In this study, we developed and evaluated a collaborative conservation initiative for monarch butterflies built with conservation psychology principles.

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Opioids are the primary therapy for acute postoperative pain, despite being associated with opioid-induced respiratory depression (OIRD). The purpose of this study was to improve nurses' knowledge, confidence, and ability to recognize, prevent, and treat OIRD in postoperative inpatients and evaluate the feasibility of using the Pasero Opioid-Induced Sedation Scale (POSS). Registered nurses completed three tools: (1) an Opioid Knowledge Self-Assessment, which was administered pre- and post-education; (2) a Confidence Scale, which was administered pre- and post-education; and (3) a POSS Perceptions and Usability Scale that was administered post-education.

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To grow, survive and reproduce under anthropogenic-induced changes, individuals must respond quickly and favourably to the surrounding environment. A species that feeds on a wide variety of prey types (i.e.

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Article Synopsis
  • - Genome editing technologies hold promise for treating human diseases, but clinical implementation faces challenges that require thorough evaluation of immunogenicity and long-term safety.
  • - Small animal models like mice and rats are insufficient for studying potential long-term effects of gene editing, leading researchers to increasingly use larger animal models such as dogs, pigs, and non-human primates, which more closely resemble human biology.
  • - This review highlights advancements in using large animal models for developing genome editing therapies, particularly targeting diseases like HIV-1, cancer, and various genetic disorders.
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Raising insects in a laboratory for release into the wild is a common conservation practice, but maintaining breeding colonies year-round can be limited by seasonal food availability. Food availability is particularly challenging for insects which depend on specific host plants. For example, our early efforts to rear the imperiled Atala hairstreak butterfly (Eumaeus atala Poey) resulted in colony failure during winter due to lack of food.

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Article Synopsis
  • The study highlights the importance of enhancing urban and suburban habitats for flower-visiting insects as land use changes contribute to their decline.
  • Over 21 months, researchers collected extensive data from 34 suburban yards in Gainesville, FL, capturing nearly 35,000 insects and 485,000 blooms to analyze various factors affecting insect populations.
  • Key findings indicate that bloom evenness and abundance significantly influence insect richness and abundance, while factors like greenspace proximity and plant type were less impactful.
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Background: In hemiparetic patients, the skeletal muscle is mainly affected with a combination of abnormalities (denervation, remodeling, spasticity, and eventually muscular atrophy).

Objective: This study examined the role of eccentric exercise in strengthening muscles of the lower extremity and ultimately improving autonomy in patients with post-stroke hemiparesis during gait.

Methods: Thirty-seven patients hemiparetic adults were recruited, randomized into a control group (n = 19) and an intervention group receiving eccentric muscle strengthening (n = 18).

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Different approaches are used in the production of recombinant adeno-associated virus (rAAV). The two leading approaches are transiently transfected human HEK293 cells and live baculovirus infection of () insect cells. Unexplained differences in vector performance have been seen clinically and preclinically.

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Deciphering the ecological roles of plant secondary metabolites requires integrative studies that assess both the allocation patterns of compounds and their bioactivity in ecological interactions. Secondary metabolites have been primarily studied in leaves, but many are unique to fruits and can have numerous potential roles in interactions with both mutualists (seed dispersers) and antagonists (pathogens and predators). We described 10 alkenylphenol compounds from the plant species Piper sancti-felicis (Piperaceae), quantified their patterns of intraplant allocation across tissues and fruit development, and examined their ecological role in fruit interactions.

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Conservation is an important organizational focus for zoos and aquariums. Organizational identity theory predicts a relationship between what is central to organizations, such as their mission statements, and their strategic activities. Based on this theory, we tested how organizational missions relate to their conservation strategies and practices.

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Purpose: To describe the role of telemedicine screening for pediatric diabetic retinopathy (DR) and to identify risk factors for pediatric DR.

Methods: The medical records of a telemedicine program at a tertiary, academic medical center over 17 months were reviewed retrospectively. Patients visiting an academic pediatric endocrinology clinic who met guidelines underwent telescreening.

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Background: Standard management in the UK for high-risk stage 1 nonseminoma germ cell tumours of the testis (NSGCTT) is two cycles of adjuvant bleomycin, etoposide (360 mg/m), and cisplatin (BEP) chemotherapy, or surveillance.

Objective: To test whether one cycle of BEP achieves similar recurrence rates to two cycles of BEP.

Design, Setting, And Participants: A total of 246 patients with vascular invasion-positive stage 1 NSGCTT or combined seminoma + NSGCTT were centrally registered in a single-arm prospective study.

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Article Synopsis
  • - AAV vectors have gained attention for gene delivery, with FDA approvals highlighting their potential, yet academic labs often lack resources to evaluate vector quality, particularly regarding genome fidelity, which is essential for vector effectiveness.
  • - Customized Fast-Seq was developed as a comprehensive method for extracting, purifying, sequencing, and analyzing packaged single-stranded AAV genomes in non-GMP settings, validated across various genome compositions, sizes, and serotypes.
  • - Fast-Seq offers several advantages over traditional sequencing methods, including lower DNA input requirements, simplified processes, compatibility with affordable sequencing tools, and an efficient 18-hour turnaround, making it cost-effective and accessible for researchers.
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Background: Many palliative care health settings that care for children and young people (CYP) at the end of life use the buccal mucosa as a route of drug administration to manage the sudden onset of symptoms, such as seizures, agitation and dyspnoea, and for breakthrough pain management. The buccal route is a minimally invasive method that delivers fast symptom relief and is useful for those with swallowing impairment or reduced enteral absorption.

Aim: This paper reports on a small retrospective study involving 26 CYP who received end-of-life care between January and December 2017 to review the advantages and disadvantages of using buccal opioids for breakthrough pain relief with a focus on diamorphine as the preferred opioid.

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The progression of chronic kidney disease can directly affect patient's health-related quality of life (HRQoL). Exercise training is a good option to reverse the impacts caused by the disease. To escape from the monotonous routine and stimulate further practice, the therapist should consider making physical activity more playful.

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Comparing newly obtained and previously known nucleotide and amino-acid sequences underpins modern biological research. BLAST is a well-established tool for such comparisons but is challenging to use on new data sets. We combined a user-centric design philosophy with sustainable software development approaches to create Sequenceserver, a tool for running BLAST and visually inspecting BLAST results for biological interpretation.

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Polyolefin thermoplastic elastomer (POE) bilayers of varying length (L) to width (W) ratio are formed through traditional polymer processing. Each layer is completely isotropic but the bilayers have an elastic recovery mismatch such that when stretched, one layer recovers to a different extent than the other. Upon stretching bilayers from low to moderate strains and releasing the bilayer bends (curvature, κ, κ < 1/L).

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Purpose: As part of wellness efforts, employers may seek to improve the nutritional quality of foods offered and consumed in cafeterias and vending machines. However, little is known about who consumes food from these venues and the types and dietary quality of the foods consumed.

Design: Cross-sectional.

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One contributing factor to the obesity epidemic is the large portion sizes served in restaurants. However, no study has looked at the parents' desire for smaller-portioned meals for their children at restaurants in the U.S.

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