Publications by authors named "Maynadie M"
Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs) and is involved in various cellular processes, including cancer development. PRMT2 expression is increased in several cancer types although its role in acute myeloid leukemia (AML) remains unknown. Here, we investigate the role of PRMT2 in a cohort of patients with AML, PRMT2 knockout AML cell lines as well as a Prmt2 knockout mouse model.
View Article and Find Full Text PDFBackground: Management of lymphoid malignancies requires substantial health system resources. Total national health expenditure might influence population-based lymphoid malignancy survival. We studied the long-term survival of patients with 12 lymphoid malignancy types and examined whether different levels of national health expenditure might explain differences in lymphoid malignancy prognosis between European countries and regions.
View Article and Find Full Text PDFRisk stratification and treatment response evaluation are key features in acute myeloid leukemia (AML) management. Immunophenotypic and molecular approaches all rely on the detection of persisting leukemic cells by measurable residual disease techniques. A new approach is proposed here by assessing medullary myeloid maturation by flow cytometry through a myeloid progenitor ratio (MPR).
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- Patients with chronic lymphocytic leukemia (CLL) have a significantly heightened risk of developing other malignancies (OMs), with a study tracking nearly 20,000 CLL patients revealing 3,513 OMs diagnosed over 129,254 years of follow-up.
- The study found that treatment with fludarabine and cyclophosphamide increased the likelihood of developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), while non-melanoma skin cancer (NMSC) and prostate cancer were common solid tumors in treated patients.
- Importantly, patients with CLL who developed OMs had lower overall survival rates, especially those diagnosed with AML and MDS, highlighting that C
Article Synopsis
- Physical activity may help reduce the risk of various cancers, but its impact on lymphoma and its subtypes remains unclear.
- This study analyzed the relationship between occupational and recreational physical activity and lymphoma risk using data from 1,117 lymphoma cases and 1,207 controls.
- Findings indicated a potential protective effect of physical activity against lymphoma in women but an increased risk of Hodgkin's lymphoma associated with recreational activity in men, suggesting overall physical activity may not significantly influence lymphoma risk.
Background: Inflammatory bowel disease [IBD] is associated with an increased risk of developing lymphoma. Although recent data have clarified the epidemiology of lymphoma in IBD patients, the clinical and pathological characteristics of lymphoma in IBD remain poorly known.
Methods: Patients with IBD and lymphoma were retrospectively identified in the framework of a national collaborative study including the Groupe d'Étude Thérapeutique des Affections Inflammatoires du Tube Digestif [GETAID] and the Lymphoma Study Association [LYSA].
Purpose: To describe Health-Related Quality of Life (HRQoL) and to identify the association between sociodemographic, clinical and psychosocial factors, and self-reported HRQoL among NHL survivors.
Methods: The data of the cancer registry specialized in hematological malignancies in Côte d'Or (France) were used to identify all patients diagnosed with follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) from 2010 to 2017. Patients were invited to complete SF-12 and other questionnaires.
Article Synopsis
- * Findings showed that younger patients with fewer comorbidities had much better access to a Specialized Haematology Unit (SHU), leading to more favorable treatment outcomes compared to older or more severely ill patients.
- * The research concluded that timely access to SHU is crucial for effective diagnosis and treatment of AML, emphasizing the need for improved care pathways, especially for the most deprived patients.
Article Synopsis
- * The study analyzed data from over 10,000 NHL cases and used advanced statistical methods to find 17 significant genetic loci linked to NHL subtypes, including a new one at HHEX.
- * Results show that while there is some shared genetic heritability among NHL subtypes, each subtype has unique genetic characteristics, with varying degrees of genetic correlation between them.
Tyrosine kinase inhibitors (TKIs) have been improving the prognosis of patients with chronic myeloid leukemia (CML), but there are still large differences in survival among European countries. This raises questions on the added value of results from population-based studies, which use real-world data, compared to results of randomized controlled trials (RCTs) involving patients with CML. There are also questions about the extent of the findings on RCTs effectiveness for patients in the general population.
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- A study analyzed health outcomes for multiple myeloma (MM) patients using data from over 3 million hospitalized adults in France, focusing on death and cardiovascular (CV) events.
- Findings showed that MM patients had a higher overall death rate compared to matched patients without MM, but the risk of CV death was similar between the two groups.
- MM patients experienced lower incidences of myocardial infarction and ischemic stroke, but had higher rates of major and intracranial bleeding, indicating a need for careful monitoring of bleeding risks in these patients.
COVID-19 Lockdown in Patients with Chronic Diseases: A Cross-Sectional Study.
Int J Environ Res Public Health
March 2022
Article Synopsis
- The study investigated the effects of the first COVID-19 lockdown on medication adherence, access to healthcare, lifestyle changes, and mental health in adults with chronic conditions.
- Despite high medication adherence at 97%, over 41% of participants missed at least one doctor’s appointment during the lockdown, with notable declines in sleep quality, physical activity, and increases in screen time.
- Urban living, poor mental health, and psychological distress were linked to unhealthy lifestyle changes, highlighting the need for targeted support in these vulnerable groups.
Lymphoid neoplasms are a heterogeneous group of lymphoid neoplastic diseases with multiple presentations, and varying prognoses. They are especially frequent in older patients (OPs) and the atypism of this frail elderly population can make the diagnostic process even more difficult. Blood lymphocyte immunophenotyping (BLI) is essential in rapid noninvasive diagnosis orientation and guides complementary investigations.
View Article and Find Full Text PDFB-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS.
Cancer Epidemiol Biomarkers Prev
May 2022
Background: A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmune conditions and the rs1800629 genotype on risk of B-cell non-Hodgkin lymphoma (NHL) subtypes. Here, we extend that evaluation using NHL subtype-specific polygenic risk scores (PRS) constructed from loci identified in genome-wide association studies of three common B-cell NHL subtypes.
Methods: In a pooled analysis of NHL cases and controls of Caucasian descent from 14 participating InterLymph studies, we evaluated joint associations between B-cell-mediated autoimmune conditions and tertile (T) of PRS for risk of diffuse large B-cell lymphoma (DLBCL; n = 1,914), follicular lymphoma (n = 1,733), and marginal zone lymphoma (MZL; n = 407), using unconditional logistic regression.
Introduction: The coronavirus disease 2019 (COVID-19) pandemic has created an unprecedented global health crisis.
Aim: To investigate the impact of the 1 COVID-19 lockdown on haemophilia patients in terms of symptoms, management, medication adherence, mental health and lifestyle behaviours.
Methods: A prospective cross-sectional phone survey using a two-part questionnaire was conducted in haemophilia patients (adults and children) followed-up in a French Haemophilia Comprehensive Care Centre between May 5, 2020 and June 2, 2020 (CLEO CD study: NCT04390126).
Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.
J Transl Genet Genom
June 2021
Article Synopsis
- * Using data from eight genome-wide association studies, the researchers estimated the fraction of the genome with runs of homozygosity (FROH) and calculated an inbreeding coefficient (F3) to analyze their impact on NHL risk among 3,061 CLL cases, 3,814 DLBCL cases, 2,784 FL cases, and 808
Article Synopsis
- * The research included 507 patients diagnosed between 2006 and 2016, revealing that 22% participated in clinical trials, and overall survival pathways varied while some patients transitioned to second-line treatments or stopped therapy.
- * Despite showing improvements in initial responses for NG-TKI, the study did not definitively conclude that NG-TKI is superior to IM in terms of survival and tolerance, indicating that further research is necessary. *
Purpose: To identify prognostic factors of invasive-disease free survival (iDFS) in women with non-metastatic hormone receptor positive (HR+) breast cancer (BC) in daily routine practice.
Methods: We performed a retrospective study using data from the Côte d'Or breast and gynecological cancer registry in France. All women diagnosed with primary invasive non-metastatic HR + BC from 1998 to 2015 and treated by endocrine therapy (ET) were included.
With improvements in acute myeloid leukemia (AML) diagnosis and treatment, more patients are surviving for longer periods. A French population of 9453 AML patients aged ≥15 years diagnosed from 1995 to 2015 was studied to quantify the proportion cured (P), time to cure (TTC) and median survival of patients who are not cured (MedS). Net survival (NS) was estimated using a flexible model adjusted for age and sex in sixteen AML subtypes.
View Article and Find Full Text PDFObjectives: An increased risk of haematological malignancies (HM) has been reported in GCA patients. Our study aimed to investigate the incidence and the type of HM occurring in GCA.
Methods: All patients with GCA and HM living in Côte d'Or (France) were identified by crossing data from the RHEMCO (Registre des Hémopathies Malignes de Côte d'Or) and those having a positive temporal artery biopsy between 1 January 2001 and 31 December 2018.
Diagnosis of B-cell chronic lymphocytic leukemia (B-CLL) is usually straightforward, involving clinical, immunophenotypic (Matutes score), and (immuno)genetic analyses (to refine patient prognosis for treatment). CLL cases with atypical presentation (e.g.
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