Publications by authors named "Mayinuer Aisha"
Article Synopsis
- This study aimed to improve the water solubility and bioavailability of loratadine, a common allergy medication, by developing it into a solid nanocrystal form.
- The loratadine nanocrystal was created using high-speed homogenization and freeze-drying, resulting in small particle sizes (425.9 nm) and improved solubility in different pH levels.
- Pharmacokinetic tests in rats showed that the nanocrystal tablets increased the drug's absorption (AUC) significantly compared to both raw and commercial versions, indicating a successful method for enhancing drug solubility and effectiveness.
As a natural flavonoid compound, rutin could scavenge free radicals effectively to achieve remarkable antioxidant and anti-photoaging activity. Unfortunately, the extremely low water solubility of rutin often leads to the poor percutaneous permeability and unsatisfactory bioavailability, which has greatly restricted its clinical application. In this study, a novel freeze-dried rutin nanocrystal was developed to improve its saturation solubility, which was further redispersed in carbopol gel to formulate the targeted rutin nanocrystal gel (NC-gel) for enhanced transdermal delivery efficiency.
View Article and Find Full Text PDFThis study was designed to survey the prevalence and risk factors of hypertension in Uygur adults in Tushala Township, Hetian area of Xinjiang Uygur Autonomous Region. Cross-sectional study of possible risk factors for hypertension was conducted in Tushala and in 28 surrounding villages using a stratified random sampling method. A modified version of the WHO STEP wise approach for risk factor survey was employed.
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