Publications by authors named "Mayara Magna Lima Melo"
Role of the STING pathway in myeloid neoplasms: a prospero-registered systematic review of principal hurdles of STING on the road to the clinical practice.
Med Oncol
April 2024
Article Synopsis
- * The STING pathway, which triggers an immune response by recognizing DNA fragments in cells, may have implications in cancer, but its specific role in myeloid neoplasms remains unclear and needs further exploration.
- * A systematic review indicates that while there is potential for STING as a therapeutic target when used alongside current treatments, more high-quality research and clinical trials are essential for understanding its impact on myeloid cancers.
Article Synopsis
- - The study investigates the role of immune checkpoint PD-L1 in Myelodysplastic Syndromes (MDS), a bone marrow disorder linked to genetic and immune issues, and its potential impact on tumor growth and prognosis.
- - Results show that patients with dyserythropoiesis have higher PD-L1 expression, and those with MDS-EB2 exhibit significant upregulation compared to MDS-EB1, suggesting a correlation between PD-L1 levels and disease severity.
- - The findings indicate that elevated PD-L1 expression may lead to poorer outcomes in MDS patients, highlighting the need for further research on anti-PD-L1 therapies for high-risk cases.
Axis and Differential Expression May Predict Pathogenesis and Poor Prognosis in De Novo Myelodysplastic Neoplasm.
Int J Mol Sci
June 2023
The aim of this study was to evaluate the expression of , , , and genes in Myelodysplastic neoplasm (MDS) to identify possible targets of ubiquitination and deubiquitination in MDS pathobiology. To achieve this, eight datasets from the Gene Expression Omnibus (GEO) database were integrated, and the expression relationship of these genes was analyzed in 1092 MDS patients and healthy controls. Our results showed that , , and were upregulated in MDS patients compared with healthy individuals, but only in mononucleated cells collected from bone marrow samples ( < 0.
View Article and Find Full Text PDFCRISPR/Cas9 small promoter deletion in H19 lncRNA is associated with altered cell morphology and proliferation.
Sci Rep
September 2021
The imprinted H19 long non-coding RNA, a knowing oncofetal gene, presents a controversial role during the carcinogenesis process since its tumor suppressor or oncogenic activity is not completely elucidated. Since H19 lncRNA is involved in many biological pathways related to tumorigenesis, we sought to develop a non-cancer lineage with CRISPR-Cas9-mediated H19 knockdown (H19-) and observe the changes in a cellular context. To edit the promoter region of H19, two RNA guides were designed, and the murine C2C12 myoblast cells were transfected.
View Article and Find Full Text PDFToll-like receptors are mutated or overexpressed in up to 50% of patients with myelodysplastic syndrome (MDS). Endogenous retroviruses (ERV) trigger TLR3 leading to interferon regulatory genes (IRFs) activation. We evaluated if the ERVs-TLR3-IRF axis activation would be linked to MDS pathogenesis and we also conducted a detailed cancer analysis of the ERVs, TLR3 and IRFs gene expression in 30 cancer types using GEPIA database.
View Article and Find Full Text PDFIntroduction: Papanicolaou test (Pap smear) is the standard screening test of pre-neoplastic lesions and cervical cancer. This study aimed to investigate cervical cancer screening results and risk factors such as age, reason for the examination, the epithelia detected in the sample, microbiota and signs of sexually transmitted infection (STIs) of women in a maternity school in Fortaleza, Ceará, Brazil.
Methods: In this cross-sectional study, data were retrieved of 353 women who underwent Pap smear between April 2016 and January 2017 at the Federal University of Ceará.