PFAS Compounds PFOA and Gen X are Teratogenic to Sea Urchin Embryos.

Per-and polyfluorinated substances (PFAS) are synthetic chemicals that are used to make fluoropolymer coatings found in many products, such as non-stick pans, clothing, cosmetics, and food packaging. These highly persistent molecules are known as "forever chemicals" since they neither degrade environmentally nor break down enzymatically within biological systems. PFAS compounds readily contaminate water sources, and as a result, certain PFAS molecules have bioaccumulated in exposed species including humans.

Bulky glycocalyx drives cancer invasiveness by modulating substrate-specific adhesion.

The majority of the eukaryotic cell surface is decorated with a layer of membrane-attached polysaccharides and glycoproteins collectively referred to as the glycocalyx. While the formation of a bulky glycocalyx has been associated with the cancer progression, the mechanisms by which the glycocalyx regulates cancer invasiveness are incompletely understood. We address this question by first documenting subtype-specific expression of the major glycocalyx glycoprotein Mucin-1 (MUC1) in breast cancer patient samples and breast cancer cell lines.

A hybrid coupled cluster-machine learning algorithm: Development of various regression models and benchmark applications.

The iterative solution of the coupled cluster equations exhibits a synergistic relationship among the various cluster amplitudes. The iteration scheme is analyzed as a multivariate discrete time propagation of nonlinearly coupled equations, which is dictated by only a few principal cluster amplitudes. These principal amplitudes usually correspond to only a few valence excitations, whereas all other cluster amplitudes are enslaved and behave as auxiliary variables [Agarawal et al.