Exploration of the inhibitory effect of on quorum sensing mediated virulence factor production and biofilm activity in : an study in model organism .

Resistance to antibiotics is leading to challenges in the treatment of microbial diseases. One amongst the various approaches to control these pathogens is quorum sensing (QS), which is used to rectify resistance issues. Blocking the bacterial QS circuit is the most reliable anti-virulence therapy to control pathogenicity-associated genes.

Correction: Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition in LasIR/RhlIR circuitry.

[This corrects the article DOI: 10.1039/C9RA06612H.].

Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition in LasIR/RhlIR circuitry.

The emergence of multidrug-resistant (MDR) bacterial strains in the last decade is astonishingly alarming. Many of the widely used antibiotics have failed to exhibit clinical efficacy against such strains. Eventually we will exhaust all the resources in our antibiotic armamentarium.