Background: Cerebellar ataxia is a disabling neurological symptom with extreme clinical and etiological heterogeneity.
Objective: To study the clinical and molecular characteristics in patients with degenerative cerebellar ataxia.
Materials And Methods: In this study, 150 South-Indian patients with degenerative cerebellar ataxia underwent a phenotype guided, sequential tiered testing.
Microsatellite loci were isolated from the genomic DNA of the Asian rice gall midge, Orseolia oryzae (Wood-Mason) using a hybridization capture approach. A total of 90 non-redundant primer pairs, representing unique loci, were designed. These simple sequence repeat (SSR) markers represented di (72%), tri (15.
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