Publications by authors named "Mayako Mori"
Article Synopsis
- Olaparib, a PARP inhibitor effective for certain cancers, has been linked to a rare but severe side effect known as drug-induced interstitial lung disease (DIILD), highlighting the need for awareness and early detection.
- This report details three cases of Japanese women with ovarian cancer who developed DIILD after taking olaparib, with symptoms ranging from fever to severe respiratory issues.
- All patients discontinued olaparib, and treatment varied based on the severity of their conditions, underscoring the importance of monitoring lung health in patients receiving this medication.
Article Synopsis
- Primary ciliary dyskinesia (PCD) is a rare genetic condition affecting ciliary function and structure, diagnosed through genotyping, with an estimated incidence of 1 in 15,000-20,000 individuals.
- A 39-year-old Japanese woman suffering from long-term respiratory issues was diagnosed with PCD after whole-exome analysis revealed novel genetic variants and confirmed lack of a key protein in her cilia.
- The case highlights that patients with certain PCD variants may experience moderate ciliary dysfunction, a reduced number of moving cilia, and potentially severe respiratory conditions.
