Publications by authors named "Mayagozel B Zhutdieva"
Ischemia/reperfusion (I/R) events are involved in the pathophysiology of numerous ocular diseases. The purpose of this study was to test the hypothesis that betulinic acid protects from I/R injury in the mouse retina. Ocular ischemia was induced in mice by increasing intraocular pressure (IOP) to 110 mm Hg for 45 min, while the fellow eye served as a control.
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- A study was conducted to investigate how chronic high cholesterol affects the retina, specifically looking at endothelial dysfunction and cell loss in the eye.
- Researchers used mice genetically modified to lack apolipoprotein E (ApoE-/-) and compared them to normal mice, measuring various factors like blood pressure and oxidative stress markers.
- The findings revealed that the ApoE-/- mice had impaired responses in retinal blood vessels and increased oxidative stress markers, but surprisingly, there was no significant difference in the total number of retinal ganglion cells or optic nerve axons between the two groups.
Muscarinic acetylcholine receptors have been implicated as potential neuroprotective targets for glaucoma. We tested the hypothesis that the lack of a single muscarinic receptor subtype leads to age-dependent neuron reduction in the retinal ganglion cell layer. Mice with targeted disruption of single muscarinic acetylcholine receptor subtype genes (M to M) and wild-type controls were examined at two age categories, 5 and 15 months, respectively.
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