Publications by authors named "Maya Sebiskveradze"
The chromatographic behavior of model compounds of biomedical significance (organic acids, amino acids, drugs) was investigated using mobile phases modified with tyloxapol. The influence of factors such as concentration of tyloxapol, content of organic modifier and pH of mobile phase on the retention factor of solutes was studied. The results were compared with the data obtained by elution with mobile phases containing Triton X-100 additives, since units of Triton X-100 are repeated in the structure of tyloxapol.
View Article and Find Full Text PDFThe chromatographic behaviour of compounds of biomedical significance was studied using micellar mobile phases modified with polyoxyethylene (20) sorbitan monooleate (Tween-80). The influence of the surfactant within the 0.75-4% concentration range on the retention factor of model compounds was investigated.
View Article and Find Full Text PDFArticle Synopsis
- The study examines how chlorpromazine and promethazine interact in rabbits when administered together versus separately.
- When given at the same time, the presence of each drug affects the other's absorption and how long they stay in the bloodstream, potentially due to liver processing and micelle formation in the digestive system.
- Chlorpromazine is rapidly taken up by the liver, influencing the levels and duration of promethazine in circulation, while promethazine alters chlorpromazine's metabolism, indicating a complex interplay between the two drugs.
The chromatographic characteristics of proteins in the presence of additives of nonionic surfactants Brij-35 and Tween-80 in the conditions of descending gradient of ammonium sulfate and phenyl-coated polymeric stationary phase were investigated. It was revealed that retention factors of proteins may be regulated by use of mentioned additives. The improvement of resolution is achieved for some hardly separated pairs of proteins, viz.
View Article and Find Full Text PDFThe interaction of carbamazepine and promethazine in rabbits has been investigated. The influence of this interaction on the processes of biotransformation in the liver was revealed. The drugs were administered as single oral doses (100 mg of each drug) as well as simultaneously with an interval of 15 min.
View Article and Find Full Text PDF