Mapping Ethanol Tolerance in Budding Yeast Reveals High Genetic Variation in a Wild Isolate.

Ethanol tolerance, a polygenic trait of the yeast , is the primary factor determining industrial bioethanol productivity. Until now, genomic elements affecting ethanol tolerance have been mapped only at low resolution, hindering their identification. Here, we explore the genetic architecture of ethanol tolerance, in the F6 generation of an Advanced Intercrossed Line (AIL) mapping population between two phylogenetically distinct, but phenotypically similar, strains (a common laboratory strain and a wild strain isolated from nature).