Publications by authors named "Maya Lewinsohn"
Spatial properties of tumour growth have profound implications for cancer progression, therapeutic resistance and metastasis. Yet, how spatial position governs tumour cell division remains difficult to evaluate in clinical tumours. Here, we demonstrate that faster division on the tumour periphery leaves characteristic genetic patterns, which become evident when a phylogenetic tree is reconstructed from spatially sampled cells.
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- * Our research screened 289 families for various hematologic malignancies and found that 3% had DDX41 mutations, primarily linked to MDS and AML, with some novel mutations identified.
- * Most asymptomatic carriers of DDX41 mutations had normal blood counts, indicating that further research is needed to understand how these mutations contribute to blood cancers.