Publications by authors named "Maya Levine-Ritterman"
β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). Here we report a role of their expression of Tet2 in regulating immune killing. Tet2 is induced in murine and human β cells with inflammation but its expression is reduced in surviving β cells.
View Article and Find Full Text PDFBackground: Inflammation in chronic active lesions occurs behind a closed blood-brain barrier and cannot be detected with MRI. Activated microglia are highly enriched for iron and can be visualized with quantitative susceptibility mapping (QSM), an MRI technique used to delineate iron.
Objective: To characterize the histopathological correlates of different QSM hyperintensity patterns in MS lesions.
The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions.
Acta Neuropathol Commun
August 2019
Activated myeloid cells and astrocytes are the predominant cell types in active multiple sclerosis (MS) lesions. Both cell types can adopt diverse functional states that play critical roles in lesion formation and resolution. In order to identify phenotypic subsets of myeloid cells and astrocytes, we profiled two active MS lesions with thirteen glial activation markers using imaging mass cytometry (IMC), a method for multiplexed labeling of histological sections.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how a specific genetic risk variant (rs7665090) near the NFKB1 gene affects astrocytes, a type of central nervous system (CNS) cell, in relation to multiple sclerosis (MS).
- The researchers found that this risk variant increases NF-κB signaling and gene expression in astrocytes, which leads to increased recruitment of immune cells (lymphocytes) into the CNS and larger lesions in MS.
- Ultimately, the research suggests that genetic factors may lead to dysfunctional astrocyte behavior, allowing more immune cells to access the CNS, and contributing to autoimmune inflammation seen in MS.