Publications by authors named "Maya Hatten-Beck"
Background: To address the challenges posed by inconsistent detection of analog insulin in commercially available insulin immunoassays, resulting in potential discrepancies in clinical findings and misdiagnosis during the investigation of factitious hypoglycemia., we aimed to evaluate the ability of the Siemens Atellica automated immunoassay to detect insulin analogs compared with LC-MS/MS.
Methods: Five insulin analogs were analyzed at 10 ng/mL spiked into serum samples, with recombinant human insulin as positive controls.
Article Synopsis
- The study highlights the advantages of liquid chromatography-tandem mass spectrometry (LC-MS/MS) over traditional immunoassays for measuring insulin and C-peptide, which can enhance patient care quality.
- Researchers from the TaMADOR consortium conducted rigorous testing to ensure the assay's precision and linearity across different laboratories, using shared materials for consistency.
- Results showed strong performance metrics, indicating that LC-MS/MS could standardize measurements and improve accuracy in diabetes research and patient management.