New phenanthrenequinones from roots and their anti-inflammatory activity on lipopolysaccharide-activated BV2 microglial cells.

The roots of yielded a total of 17 compounds, comprising two new compounds (1-2), one new natural product (3), and 14 known compounds (4-17). The structures of new compounds were determined through the analysis of their spectroscopic data, including NMR, MS, UV, FT-IR, optical rotation, and CD. The anti-inflammatory activity of the isolated pure compounds was assessed using lipopolysaccharide-activated BV2 microglial cells.

A new phenanthrene with a spirolactone ring from .

Dendroochreatene (), a new phenanthrene derivative with a spirolactone ring, was isolated from the whole plant together with 11 known compounds (-). The structure of the new compound was elucidated spectroscopically and phenolic compounds were firstly reported from Moscatilin (), major compound isolated from was found to be cytotoxic toward H460 lung-cancer cells, with an IC value of 147.3 ± 0.

New Phenolic Glycosides from Lindl. var. and Their Cytotoxicity against Human Breast Cancer Cells.

The phytochemical investigation of the whole plants of Lindl. var. led to the discovery of three new phenolic glycosides, i.

Conduction system pacing: promoting the physiology to prevent heart failure.

Cardiac conduction system pacing provides physiological ventricular activation by directly stimulating the conduction system. This review describes the two types of conduction system pacing: His bundle pacing (HBP) and left bundle area pacing (LBAP). The most significant advantage of HB pacing is that it can provide a regular, narrow QRS; however, the disadvantages are challenging implantation and a high risk of re-intervention due to lead dislodgement and the development of high pacing threshold.

-Glucosidase Inhibitory Activity and Anti-Adipogenic Effect of Compounds from .

Chemical investigation of revealed 11 phenolic compounds, and the structures of these compounds were determined by analysis of their NMR and HR-ESI-MS data. All compounds were investigated for their -glucosidase inhibitory activity and anti-adipogenic properties. Phoyunnanin E () and phoyunnanin C () showed the most potent -glucosidase inhibition by comparing with acarbose, which was used as a positive control.

Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from and Their -Glucosidase Inhibitory Activity.

A phytochemical investigation on the whole plants of revealed the presence of three new biphenanthrene derivatives named aerimultins A-C (-) and a new natural phenylpropanoid ester dihydrosinapyl dihydroferulate (), together with six known compounds (-). The structures of the new compounds were elucidated by analysis of their spectroscopic data. All of the isolates were evaluated for their -glucosidase inhibitory activity.

New Fluorene Derivatives from and Their -Glucosidase Inhibitory Activity.

Two new compounds, dihydrodengibsinin () and dendrogibsol (), were isolated from the whole plant of , together with seven known compounds (-). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosidase inhibitory activities.