Publications by authors named "May Tayyem"
Background: Skin and soft tissue infections (SSTIs) present significant treatment challenges. These infections often require systemic antibiotics such as vancomycin, which poses a risk for increased bacterial resistance. Topical treatments are hindered by the barrier function of the skin, and microneedles (MNs) offer a promising solution, increasing patient compliance and negating the need for traditional needles.
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- - Bacteria can hide inside host cells like macrophages to evade antibiotics, prompting research on using PLGA nanoparticles to deliver antibiotics to these intracellular bacteria.
- - Different sizes of Rhodamine-B conjugated PLGA nanoparticles were tested to see how well they were taken up by macrophages and epithelials, showing larger nanoparticles had better uptake by macrophages.
- - In tests against intracellular infections, larger antibiotic-loaded PLGA nanoparticles were more effective against K. pneumoniae, but not against S. aureus, suggesting that there's no universal solution for targeting all types of intracellular infections.