Publications by authors named "May Rajtboriraks"
Increasing evidence suggests that anesthesia may induce developmental neurotoxicity, yet the influence of genetic predispositions associated with congenital anomalies on this toxicity remains largely unknown. Children with congenital heart disease often exhibit mutations in cilia-related genes and ciliary dysfunction, requiring sedation for their catheter or surgical interventions during the neonatal period. Here we demonstrate that briefly exposing ciliopathic neonatal mice to ketamine causes motor skill impairments, which are associated with a baseline deficit in neocortical layer V neuron apical spine density and their altered dynamics during motor learning.
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- Oral mucositis (OM) is a painful side effect of cancer treatments, and palifermin is currently the only treatment for some patients.
- This study utilized an oral mucositis model on a chip to test the effects of cancer therapies like cisplatin and radiation on human keratinocytes and investigated the protective effects of keratinocyte growth factor (KGF).
- Results showed that KGF significantly reduced cell death and promoted healing, suggesting it could be a valuable treatment option, while also identifying inflammatory cytokines that may be targeted for future therapies.
Background: Neurologic impairments are a significant concern for survivors after pediatric cardiac surgery with cardiopulmonary bypass (CPB). We have previously shown that mesenchymal stromal cell (MSC) delivery through CPB has the potential to mitigate the effects of CPB on neural stem/progenitor cells. This study assessed the dose effects of MSCs.
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