Use of nutritional supplements in an ambulatory elderly population.

The use of nutritional supplements by 3,192 ambulatory elderly participants in a health screening program is described. The 2,009 women used vitamin (45.5 per cent) and mineral (22.

Isolation and characterisation of the Xenopus laevis albumin genes: loss of 74K albumin gene sequences by library amplification.

The blood of the frog X.laevis contains 2 albumins of 68,000 and 74,000 daltons which are encoded in the liver by two related mRNAs. When an amplified X.

Prescribed and nonprescribed drug use in an ambulatory elderly population.

Drug usage was studied in an ambulatory geriatric population. Prescription and nonprescription drug use is described for 3,192 participants in a geriatric screening program (the Dunedin Program). Average drug use by these participants was found to be 3.

Glucocorticoid receptor of X. laevis: possible effect of phosphorylation on hormone binding.

The cytoplasmic glucocorticoid receptor of X. laevis liver has a high affinity for [3H]dexamethasone (Kd, 0.3 x 10(-8) M), and its binding specificity for a variety of steroids is similar to that found for mammalian glucocorticoid receptors.

Psychotropic drug use in an ambulatory elderly population.

Medication histories were obtained from 3,192 ambulatory elderly persons participating in a health screening program. A total of 2,009 (63%) women and 1,183 (37%) men were included in the drug use study. Flurazepam, pentobarbital and the combination of amobarbital and secobarbital were used by 4.

Quantitation of DNase I sensitivity in Xenopus chromatin containing active and inactive globin, albumin and vitellogenin genes.

The disappearance of defined restriction fragments of the beta 1-globin, an albumin and the A1 vitellogenin gene was quantitated after DNase I digestion and expressed by a sensitivity factor defined by a mathematical model. Analysis of naked DNA showed that the gene fragments have similar but not identical sensitivity factors. DNase I digestion of chromatin revealed for the same gene fragments sensitivity factors differing over a much wilder range.

A method of obtaining an epithelial attachment on an endosseous implant.

An attempt was made to obtain a soft-tissue seal around the neck of an endosseous implant using a section of root from another tooth in the oral cavity. Six implants were placed bilaterally in the mandibular first molar regions of three monkeys. Four of the six implants were lost during the experimental period.

Diarrhoea as a side effect of amoxycillin therapy.

The incidence of loose bowel actions in hospitalized children who were receiving amoxycillin mixture has been studied. A total of 293 patients were observed for the occurrence of loose bowel actions considered not to be due to their disease-state; some 19% of these patients suffered this side effect. The incidence was extremely high in the youngest children, but it diminished as age increased.

Pharmacists' clinical role expanded.

A hospital used management engineering to achieve more effective utilization of its pharmacy staff so that pharmacists' clinical role could be expanded without increases in staff or costs.

A computer program for parenteral nutrition solution preparation.

The preparation of single-bottle parenteral nutrition solutions for neonates has long posed a problem for pharmacists. Frequent formulation changes and the need for rapid supply of solutions after prescription has led to a variety of preparation techniques being developed. An interactive computer program is described which enables a nonspecialist pharmacist staff to safely and quickly produce the formula, label and fully document it from a prescription for parenteral nutrition.

Drug interactions and multiple drug administration.

Effects of multiple drug administration on adverse drug reactions were studied in 10,518 patients hospitalized on a general medical service during a five-year period. Nine index drug groups, including analgesic, antacid, antiarrhythmic, antimicrobic, anticoagulant, antihypertensive, anti-inflammatory, diuretic, and sedative-tranquilizer drugs, were selected for study. The average number of adverse drug reactions for the anticoagulant and antihypertensive drug groups was higher (p less than 0.

Dinoflagellates: fossil motile-stage tests from the upper cretaceous of the northern new jersey coastal plain.

Fossil dinoflagellate tests have been considered to represent encysted, nonmotile stages. The discovery of flagellar porelike structures and probable trichocyst pores in the Upper Cretaceous genus Dinogymnium suggests that motile stage tests are also preserved as acid-resistant, organic-walled microfossils.

Drug-associated deaths of medical inpatients.

Of 7,423 medical inpatients, 16 (0.22%) died of drug-associated causes. The overall mortality for all medical inpatients was 6.