Design, facile synthesis and anthelmintic activity of new -substituted 6-methoxybenzothiazole-2-carbamates. Part II.

In the framework of pursuing the design and synthesis of a new series of substituted 6-methoxybenzothiazole-2-carbamates as potential anthelmintics, and as a continuation of the expended efforts in part I, we have set out to develop novel compounds with enhanced anthelmintic activity by blocking the 6-position of benzothiazole with side chains of different polarities. Guided by the findings in part I, and reporting the paramphistomicidal activity of oxadiazoline derivatives and , we aimed to synthesize target benzothiazoles designed to comprise some planar heterocyclic ring systems, namely, 1,3,4-oxadiazoles and 1,2,4-triazoles, bearing a variety of hydrophobic and hydrophilic components. The synthesis of the desired compounds was primarily achieved by cyclization of 6-acetohydrazide, .

Prevalence and predictors of pulmonary hypertension in elderly patients with isolated diastolic heart failure.

Background: Despite the growing recognition that pulmonary hypertension can develop in diastolic heart failure; its clinical significance remains poorly defined.

Aim: We sought to explore the prevalence and predictors of pulmonary hypertension in elderly patients with isolated diastolic heart failure.

Methods: We enrolled 100 consecutive elderly patients with isolated diastolic heart failure.