Publications by authors named "Maxwell W G Miner"
Article Synopsis
- Non-invasive imaging techniques, like PET, play a crucial role in detecting and characterizing cancer, particularly in sensitive areas such as the brain, with a focus on a radiolabeled folate analogue that targets cancer cells.
- In a study involving BDIX rats with implanted glioma cells, researchers conducted PET/CT imaging to evaluate the efficacy of the folate analogue compared to another imaging agent, [F]FDG, over time.
- Results showed that the folate analogue significantly increased tumor-to-brain uptake ratios, indicating better detection of gliomas, and confirmed the presence of folate receptors in tumor tissues, suggesting potential for human application.
Bexmarilimab is a new humanized monoclonal antibody against common lymphatic endothelial and vascular endothelial receptor-1 (CLEVER-1) and is in clinical trials for macrophage-guided cancer immunotherapy. In addition being associated with cancer, CLEVER-1 is also associated with fibrosis. To facilitate prospective human PET studies, we preclinically evaluated Zr-labeled bexmarilimab in rabbits.
View Article and Find Full Text PDFIncreased glutamine metabolism by macrophages is associated with development of atherosclerotic lesions. Positron emission tomography/computed tomography (PET/CT) with a glutamine analog (2S,4)-4-F-fluoroglutamine (F-FGln) allows quantification of glutamine consumption . Here, we investigated uptake of F-FGln by atherosclerotic lesions in mice and compared the results with those obtained using the glucose analog 2-deoxy-2-F-fluoro--glucose (F-FDG).
View Article and Find Full Text PDFPurpose: The three positron emission tomography (PET) imaging compounds: (2,4)-4-[F]Fluoroglutamine ([F]FGln), -[methyl-C]Methionine ([C]Met), and 2-deoxy-2-[F]fluoro--glucose ([F]FDG) were investigated to contrast their ability to image orthotopic BT4C gliomas in BDIX rats. Two separate small animal imaging systems were compared for their tumor detection potential. Dynamic acquisition of [F]FGln was evaluated with multiple pharmacokinetic models for future quantitative comparison.
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