Publications by authors named "Maxwell V Dacquel"
Article Synopsis
- This study aims to enhance diagnostic accuracy for rapidly progressive dementia (RPD) by analyzing various cerebrospinal fluid (CSF) biomarkers, considering the overlap in symptoms and diagnostic challenges among different dementia types.
- Researchers compared biomarker levels in 78 patients with RPD, 35 with typical neurodegenerative diseases, and 72 control subjects, focusing on multiple factors like neuroinflammation and neurodegeneration.
- Results indicate that specific biomarkers can effectively distinguish between different underlying causes of RPD, with a multivariate model achieving 89% accuracy in identifying treatment-responsive cases.
Background: The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer's disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain.
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