Retrospective evaluation of the influence of phenoxybenzamine pretreatment on intraoperative cardiovascular variables in dogs with pheochromocytoma.

Objective: To compare cardiovascular outcomes in dogs undergoing adrenalectomy for pheochromocytoma with and without phenoxybenzamine pretreatment.

Animals: A total of 65 medical records from dogs at 5 veterinary hospitals.

Procedure: Records from January 2004 to December 2021 were evaluated for systolic, mean, and diastolic arterial pressures; numbers of hypertensive and hypotensive episodes; highest and lowest systolic arterial pressure differences; dose and duration of phenoxybenzamine; and presence of intraoperative arrhythmias.

Effects of luteinizing hormone receptor activation in immortalized neoplastic canine T lymphocytes.

Objective: The expression of luteinizing hormone (LH) receptors has been reported in canine nonneoplastic and neoplastic lymphocytes. This study aimed to determine the effect of LH receptor activation in neoplastic canine T lymphocytes.

Methods: Cell lines (CLC, CLK, EMA) derived from 3 dogs with primary T-cell lymphoma were used.

Transport starter data kit: Historical passenger and freight transport data for selected countries in Africa, Asia, and South America.

The demand for data-driven models to inform sustainable transportation planning has become more important as countries address the complexities of urban mobility. However, data collection and curation are time-consuming and can be challenging due to data inaccessibility and inaccuracy. The Transport Starter Data Kit therefore aims to address these challenges, offering a one-stop-shop for transport modelling-related data.

Palaeohistology of Macrospondylus bollensis (Crocodylomorpha: Thalattosuchia: Teleosauroidea) from the Posidonienschiefer Formation (Toarcian) of Germany, with insights into life history and ecology.

The Posidonienschiefer Formation of southern Germany has yielded an array of incredible fossil vertebrates. One of the best represented clades therein is Teleosauroidea, a successful thalattosuchian crocodylomorph group that dominated the coastlines. The most abundant teleosauroid, Macrospondylus bollensis, is known from a wide range of body sizes, making it an ideal taxon for histological and ontogenetic investigations.

Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank.

Whole-genome sequencing (WGS), whole-exome sequencing (WES) and array genotyping with imputation (IMP) are common strategies for assessing genetic variation and its association with medically relevant phenotypes. To date, there has been no systematic empirical assessment of the yield of these approaches when applied to hundreds of thousands of samples to enable the discovery of complex trait genetic signals. Using data for 100 complex traits from 149,195 individuals in the UK Biobank, we systematically compare the relative yield of these strategies in genetic association studies.

Why are healthcare professionals leaving NHS roles? A secondary analysis of routinely collected data.

Background: Much policy attention focuses on increasing the supply of workers in the English NHS but there has been less attention paid to the rise in leavers. This paper seeks to explore how existing data sets can illuminate the decision-making of leavers and inform actions that could mitigate this.

Method: Secondary analysis of routinely collected data from 79 workforce projects in the UK (n = 46 339 participants) over a 4-year (2019-2023) period was undertaken.

Swiss ichthyosaurs: a review.

Switzerland is an ichthyosaur country: it has a rich record of marine reptile fossils, particularly the fish-shaped ichthyosaurs, and the according research. Here, we provide an overview over the 12 or more genera and at least 13 species plus numerous fragmentary remains of ichthyosaurs from the Triassic to the Cretaceous that have been discovered in twelve cantons thus far, of which four species are based on Swiss holotypes. This wealth of ichthyosaur species can be explained by their abundance in the Middle Triassic conservation deposits (Konservat Lagerstätte) of Monte San Giorgio, as well as occasional discoveries in strata of Middle Triassic to Early Cretaceous age.

elution of amikacin, cefazolin, gentamicin, ampicillin/sulbactam, and meropenem from a commercially available calcium sulfate delivery kit.

Introduction: The use of implantable antibiotic beads has become a frequent treatment modality for the management of surgical site infections in human and veterinary medicine. The objective of this study is to describe the elution kinetics of five antibiotics from a commercially available calcium sulfate antibiotic delivery kit. A secondary goal was to compare elution concentrations with minimal inhibitory concentrations (MIC) for commonly encountered bacteria from the University of Florida's veterinary microbiology laboratory database.

Ultrasound-guided retromammillary injections in dogs: a feasibility, descriptive and anatomical study.

Objective: To evaluate the feasibility of an ultrasound-guided technique targeting the medial branches of the dorsal ramus of the spinal nerves (DRSN) by injecting a dye solution at the caudal aspect of the base of lumbar mammillary processes [i.e. the retromammillary (RM) space].

Australian fresh frozen plasma audit: A National Blood Transfusion Committee and Blood Matters collaboration.

Background: There is a paucity of high-quality data to guide appropriate fresh frozen plasma transfusion with current recommendations based on consensus opinion. The limitations of the product and testing modalities are poorly understood with the rare but potentially serious side effects underappreciated. Combined this has resulted in the widespread misuse of FFP.

The Effects of a Core Stabilization Training Program on the Performance of Functional Tasks in Firefighters.

The purpose of this study was to observe if core stabilization training plays a significant role in firefighter time-to-completion during a functional performance test. A within subjects study design was used in which subjects ( = 13, 84.6% male, 33.

Oldest record of Machimosaurini (Thalattosuchia, Teleosauroidea): teeth and scavenging traces from the Middle Jurassic (Bajocian) of Switzerland.

The Jurassic period was a time of major diversification for Mesozoic marine reptiles, including Ichthyosauria, Plesiosauria and thalattosuchian Crocodylomorpha. The latter originated in the Early Jurassic and thrived during the Late Jurassic. Unfortunately, the Middle Jurassic, a crucial time in their evolution, has a poor fossil record.

A survey of undergraduate medical students' gender awareness and bias: the Newfoundland and Labrador perspective.

Background: Female physicians and patients experience gender bias in healthcare. The purpose of this research is to explore medical students' gender bias toward physicians and patients and whether their bias varies by gender.

Methods: We surveyed medical students at Memorial University between November 2020 and April 2021.

A large new Middle Jurassic ichthyosaur shows the importance of body size evolution in the origin of the Ophthalmosauria.

The Middle Jurassic is an important time period for the evolutionary history of marine reptiles as it represented a transitional phase for many clades. Notably, in ichthyosaurs, many early parvipelvian taxa went extinct. The Middle Jurassic saw the emergence of the derived Ophthalmosauria, ultimately becoming the dominant ichthyosaurian clade by the end of the epoch.

Further defining the roles and impact of genetic counselors in the biotechnology and pharmaceutical industry.

As personalized medicine has gained traction, drug development models in the biotechnology and pharmaceutical industry (BPI) have increasingly sought to address medical conditions with a genetic component, creating an opportunity for genetic counselors (GCs) to fill new roles and utilize their unique training to contribute to drug development. Despite the potential for GCs in BPI, literature around the role of GCs in this industry has been limited. Our mixed methods study aimed to assess how the roles of GCs in BPI have evolved since 2016, investigate the value of and opportunity for GCs in this industry, and further characterize their motivation and job satisfaction.

Management of open wounds in dogs using a bioresorbable polymeric wound matrix: 14 Cases (2019-2021).

The objective of this retrospective case series is to evaluate clinical outcomes associated with the use of a bioresorbable polymeric wound matrix (MicroLyte Vet; Imbed Biosciences) for the management of soft tissue wounds of various etiologies in dogs. Medical records were reviewed between August 2019 and November 2021 for signalment, wound etiology, location, size, initial wound management, antibiotic therapy, time to initial application, number of applications, time between applications, secondary dressing used, time to wound closure, complications, and clinical outcomes. Time to initial application ranged from 1 to 61 days (median, 7.

Ontogenetic variation in the cranium of with implications for the evolution of ichthyosaurian cranial development.

Unlabelled: Relatively complete ontogenetic series are comparatively rare in the vertebrate fossil record. This can create biases in our understanding of morphology and evolution, since immaturity can represent a source of unrecognized intraspecific variation in both skeletal anatomy and ecology. In the extinct marine reptile clade Ichthyopterygia, ontogenetic series were widely studied only in some Jurassic genera, while the ontogeny of the oldest and most basal members of the clade is very poorly understood.

Adrenal tumors treated by adrenalectomy following spontaneous rupture carry an overall favorable prognosis: retrospective evaluation of outcomes in 59 dogs and 3 cats (2000-2021).

Objective: To conduct a retrospective multi-institutional study reporting short- and long-term outcomes of adrenalectomy in patients presenting with acute hemorrhage secondary to spontaneous adrenal rupture.

Animals: 59 dogs and 3 cats.

Methods: Medical records of dogs and cats undergoing adrenalectomy between 2000 and 2021 for ruptured adrenal masses were reviewed.