Non-strategic ignorance: Considering the potential for a paradigm shift in evidence-based mental health.

Randomised controlled trials form a central building block within the prevailing evidence-based mental health paradigm. Both methodology and paradigm have been widely problematised since their emergence in the mid-late twentieth century. We draw on the concept of 'strategic ignorance' to understand why the paradigm still prevails.

Experimental Characterization of Hb Flurlingen (HBA2: c.177 C > G, p.His > Gln) and Hb Boghé (HBA2: c.177 C > A, p.His > Gln) Reveals Contradictory HBA2 Expression and Translation Patterns Despite Identical Amino Acid Substitutions.

In this study, we describe the clinical features and provide experimental analyses of Hb Flurlingen (HBA2: c.177 C > G, p.His > Gln) that contrasted with Hb Boghé (HBA2: c.

Molecular and cellular analysis of three novel alpha2-globin gene promoter mutations [HBA2: c.-59C>T], [HBA2: c.-81C>A] and [HBA2: c.-91G>A] reveal varying patterns of transcriptional and translational activities.

While point mutations affecting the promoter region of β-globin gene are widely described, there are no well characterised reports of any point mutations currently found in the promoter of the α2-globin (HBA2) gene. We present clinical and experimental data for three novel HBA2 gene core and proximal promoter mutations. Using an in vitro system designed to assess the impact of point mutations, the three novel [HBA2:c.

Finding a voice: a journey towards being assertive.

This is a case study of two depressed women who were able to benefit from a 16-week course of Interpersonal Psychotherapy. This well-established brief psychotherapy has become increasingly available throughout the UK. The focus of this biopsychosocial approach that is on change within the patients interpersonal world means a more active goal-focused approach that addresses symptomatic and emotional concerns using the individuals narrative.