The Ovarian Transcriptome of Reproductively Aged Multiparous Mice: Candidate Genes for Ovarian Cancer Protection.

In middle-aged women, the decline of ovarian follicle reserve below a critical threshold marks menopause, leading to hormonal, inflammatory, and metabolic changes linked to disease. The highest incidence and mortality of sporadic ovarian cancer (OC) occur at post-menopause, while OC risk is reduced by full-term pregnancies during former fertile life. Herein, we investigate how parity history modulates the ovarian transcriptome related to such declining follicle pool and systemic inflammation in reproductively-aged mice.

Efficient synthesis and antioxidant activity of novel -propargyl tetrahydroquinoline derivatives through the cationic Povarov reaction.

New N-propargyl tetrahydroquinolines have been synthesized efficiently through the cationic Povarov reaction (a domino Mannich/Friedel-Crafts reaction), catalyzed by Indium (III) chloride (InCl), from the corresponding -propargylanilines preformed, formaldehyde and -vinylformamide, with good to moderate yields. All tetrahydroquinoline derivatives obtained were evaluated as free radical scavengers. Results showed that compound presents a potent antioxidant effect compared with ascorbic acid, used as a reference compound.