Polymorphism rs2275913 of Interleukin-17A is related to more intensive therapy with disease-modifying anti rheumatic drugs in Mexican patients with Rheumatoid Arthritis.

Aim: The study has two aims: 1) to evaluate the association of IL-17 polymorphism rs2275913 with RA severity and 2) to evaluate if this particular SNP is associated with susceptibility for RA in Mexican patients.

Methods: Seventy-six RA patients and ninety-four healthy controls were included in the study. RA patients were evaluated according to DAS 28.

Impact of Chronic Glucocorticoid Treatment on Cardiovascular Risk Profile in Patients with Systemic Lupus Erythematosus.

Background: Systemic lupus erythematosus is highly associated with premature atherosclerosis and cardiovascular events. The origin of this subclinical atherosclerosis has been attributed mainly to the inflammatory nature of the disease.

Objective: To assess the effect of long-term use of glucocorticoids on cardiovascular risk in patients with systemic lupus erythematosus.

Increased concentrations of soluble CD40 ligand platelet in patients with primary antiphospholipidic syndrome.

Objective: To determine the concentrations of sCD40L in patients with PAPS, and establish its association with the number of thrombosis.

Patients And Methods: We included patients with PAPS and healthy controls of the same age and sex. For analysis, patients with PAPS were divided into 2 groups: 1) patients with 1 thrombosis, and 2) patients with >1 thrombosis.