Publications by authors named "Maximiliano C Kneubil"
Gliomas represent 80% of all primary malignant brain tumors in adults. In view of this public health problem, the early detection through sensitive and specific molecular tumor markers analysis can help to improve gliomas diagnosis and prognosis as well as their staging, assessment of therapeutic response and detection of recurrence. Therefore, this review focuses in current gliomas tumor markers, IDH-1/2, 1p/19q, MGMT, ATRX, TERT, H3, EGFR, BRAF and Ki67 used in clinic worldwide and their importance to early detection, glioma histological and molecular classification as well as in predicting patient's therapeutic response.
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- Literature indicates that HER2/neu positive breast cancer is more responsive to radiation therapy, especially when targeting specific receptors.
- A study involving 466 patients with HER2/neu positive tumors compared outcomes from three treatment methods: quadrantectomy plus conventional radiotherapy, quadrantectomy plus intra-operative radiotherapy, and mastectomy without radiotherapy.
- After an average follow-up of over four years, results showed varying 5-year recurrence rates, highlighting the effectiveness of external radiotherapy combined with trastuzumab, while emphasizing the need for better risk stratification based on hormonal receptor status.
Background: The selections of nipple-sparing mastectomy (NSM) are principally depending on oncologic indication and oncologic safety. The main complication of NSM is nipple areolar complex (NAC) necrosis, and it is usually related to surgical technique. However, the patients' clinicopathological factors should be also considered.
View Article and Find Full Text PDFBackground: Our purpose was to evaluate the locoregional recurrence (LRR) of patients with false-negative, frozen-section or close margins of retroareolar specimen in nipple-sparing mastectomy (NSM) procedure.
Methods: From 2002-2008, we recruited patients who had atypia or presence of cancer cells in definitive histology of retroareolar tissue despite of absence of tumor cell in intraoperative retroareolar frozen section. We also included the close margin cases defined as the presence of tumor cells at the first frozen section, but after deeper core out of retroareolar tissue were revealed free of malignancy.
Article Synopsis
- Trastuzumab combined with chemotherapy is the recommended treatment for HER2 positive breast cancer, but there is limited research on its effects in elderly patients.
- A systematic review indicated a significant 47% reduction in risk for those over 60 receiving trastuzumab compared to chemotherapy alone, while cardiac events were relatively low at 5%.
- Despite the effectiveness of trastuzumab in this age group, it's important to assess individual health factors and address ongoing concerns about cardiac safety during treatment.
Objective: The use of the left internal thoracic artery in coronary artery bypass surgery is currently recognized as the best option, providing lesser incidence of cardiovascular events and superior long-term survival. As a result, great expansion of bilateral internal thoracic artery (ITAs) grafts has been observed, with additional demonstration of improved long-term survival. Therefore the aim of this study was to examine and compare the histomorphometric structure among different segments of the left and right ITA.
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