Publications by authors named "Maximilian M Kreft"
Article Synopsis
- Eukaryotic cells can change shape and move through tight spaces, but how this relates to their nuclei is still not well understood.
- This study focuses on mesenchymal cancer cell nuclei as they travel through narrow hydrogel channels, revealing that migration speed and frequency peak when channel widths are similar to the nuclear diameter.
- The researchers discovered that as nuclei migrate through these channels, they deform and change shape, with both pulling and pushing forces from the cytoskeleton playing a role in their movement under confinement.
